Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation

Nicoletta Di Simone; Riccardo Marana; Roberta Castellani; Fiorella Di Nicuolo; M. C. D'Alessio; E. Raschi; M. O. Borghi; P. P. Chen; Maurizio Sanguinetti; Alessandro Caruso; P. L. Meroni

doi:10.1002/art.27361

Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation

Nicoletta Di Simone
, Riccardo Marana
, Roberta Castellani
, Fiorella Di Nicuolo
, M. C. D'Alessio
, E. Raschi
, M. O. Borghi
, P. P. Chen
, Maurizio Sanguinetti
, Alessandro Caruso
, P. L. Meroni

University of Milan
University of California at Los Angeles

Risultato della ricerca: Contributo in rivista › Articolo › peer review

49 Citazioni (Scopus)

Abstract

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in blastocyst implantation and is down-regulated in preeclampsia and in hypertensive pregnancy disorders associated with defective extravillous trophoblast invasion. Defective placentation and severe preeclampsia are also features of the antiphospholipid syndrome (APS). The purpose of this study was to investigate whether abnormal HB-EGF expression plays a pathogenic role in antiphospholipid antibody (aPL)-mediated defective placentation.

Lingua originale	Inglese
pagine (da-a)	1504-1512
Numero di pagine	9
Rivista	Arthritis and Rheumatism
DOI	https://doi.org/10.1002/art.27361
Stato di pubblicazione	Pubblicato - 2010

Keywords

Adult
Antibodies, Antiphospholipid
Antibodies, Monoclonal
Anticoagulants
Antiphospholipid Syndrome
Blotting, Western
Cells, Cultured
Down-Regulation
Female
Gene Expression
Heparin, Low-Molecular-Weight
Humans
Intercellular Signaling Peptides and Proteins
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Pilot Projects
Placenta Diseases
Pregnancy
RNA, Messenger
Trophoblasts
beta 2-Glycoprotein I

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10.1002/art.27361

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Di Simone, N., Marana, R., Castellani, R., Di Nicuolo, F., D'Alessio, M. C., Raschi, E., Borghi, M. O., Chen, P. P., Sanguinetti, M., Caruso, A., & Meroni, P. L. (2010). Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation. Arthritis and Rheumatism, 1504-1512. https://doi.org/10.1002/art.27361

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title = "Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation",

abstract = "Heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in blastocyst implantation and is down-regulated in preeclampsia and in hypertensive pregnancy disorders associated with defective extravillous trophoblast invasion. Defective placentation and severe preeclampsia are also features of the antiphospholipid syndrome (APS). The purpose of this study was to investigate whether abnormal HB-EGF expression plays a pathogenic role in antiphospholipid antibody (aPL)-mediated defective placentation.",

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author = "\{Di Simone\}, Nicoletta and Riccardo Marana and Roberta Castellani and \{Di Nicuolo\}, Fiorella and D'Alessio, \{M. C.\} and E. Raschi and Borghi, \{M. O.\} and Chen, \{P. P.\} and Maurizio Sanguinetti and Alessandro Caruso and Meroni, \{P. L.\}",

year = "2010",

doi = "10.1002/art.27361",

language = "English",

pages = "1504--1512",

journal = "Arthritis and Rheumatism",

issn = "0004-3591",

publisher = "John Wiley \& Sons Inc.",

}

Di Simone, N, Marana, R, Castellani, R, Di Nicuolo, F, D'Alessio, MC, Raschi, E, Borghi, MO, Chen, PP, Sanguinetti, M, Caruso, A & Meroni, PL 2010, 'Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation', Arthritis and Rheumatism, pagg. 1504-1512. https://doi.org/10.1002/art.27361

Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation. / Di Simone, Nicoletta; Marana, Riccardo; Castellani, Roberta et al.
In: Arthritis and Rheumatism, 2010, pag. 1504-1512.

Risultato della ricerca: Contributo in rivista › Articolo › peer review

TY - JOUR

T1 - Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation

AU - Di Simone, Nicoletta

AU - Marana, Riccardo

AU - Castellani, Roberta

AU - Di Nicuolo, Fiorella

AU - D'Alessio, M. C.

AU - Raschi, E.

AU - Borghi, M. O.

AU - Chen, P. P.

AU - Sanguinetti, Maurizio

AU - Caruso, Alessandro

AU - Meroni, P. L.

PY - 2010

Y1 - 2010

N2 - Heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in blastocyst implantation and is down-regulated in preeclampsia and in hypertensive pregnancy disorders associated with defective extravillous trophoblast invasion. Defective placentation and severe preeclampsia are also features of the antiphospholipid syndrome (APS). The purpose of this study was to investigate whether abnormal HB-EGF expression plays a pathogenic role in antiphospholipid antibody (aPL)-mediated defective placentation.

AB - Heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in blastocyst implantation and is down-regulated in preeclampsia and in hypertensive pregnancy disorders associated with defective extravillous trophoblast invasion. Defective placentation and severe preeclampsia are also features of the antiphospholipid syndrome (APS). The purpose of this study was to investigate whether abnormal HB-EGF expression plays a pathogenic role in antiphospholipid antibody (aPL)-mediated defective placentation.

KW - Adult

KW - Antibodies, Antiphospholipid

KW - Antibodies, Monoclonal

KW - Anticoagulants

KW - Antiphospholipid Syndrome

KW - Blotting, Western

KW - Cells, Cultured

KW - Down-Regulation

KW - Female

KW - Gene Expression

KW - Heparin, Low-Molecular-Weight

KW - Humans

KW - Intercellular Signaling Peptides and Proteins

KW - Matrix Metalloproteinase 2

KW - Matrix Metalloproteinase 9

KW - Pilot Projects

KW - Placenta Diseases

KW - Pregnancy

KW - RNA, Messenger

KW - Trophoblasts

KW - beta 2-Glycoprotein I

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KW - Antibodies, Antiphospholipid

KW - Antibodies, Monoclonal

KW - Anticoagulants

KW - Antiphospholipid Syndrome

KW - Blotting, Western

KW - Cells, Cultured

KW - Down-Regulation

KW - Female

KW - Gene Expression

KW - Heparin, Low-Molecular-Weight

KW - Humans

KW - Intercellular Signaling Peptides and Proteins

KW - Matrix Metalloproteinase 2

KW - Matrix Metalloproteinase 9

KW - Pilot Projects

KW - Placenta Diseases

KW - Pregnancy

KW - RNA, Messenger

KW - Trophoblasts

KW - beta 2-Glycoprotein I

UR - http://hdl.handle.net/10807/29513

U2 - 10.1002/art.27361

DO - 10.1002/art.27361

M3 - Article

SN - 0004-3591

SP - 1504

EP - 1512

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

ER -

Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation

Abstract

Keywords

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