TY - JOUR
T1 - Decrease in N-Acetylaspartate Following Concussion May Be Coupled to Decrease in Creatine.
AU - Vagnozzi, Roberto
AU - Signoretti, Stefano
AU - Floris, Roberto
AU - Marziali, Simone
AU - Manara, Massimo
AU - Amorini, Angela Maria
AU - Belli, Antonio
AU - Di Pietro, Valentina
AU - D'Urso, Serafina
AU - Pastore, Francesco S.
AU - Lazzarino, Giuseppe
AU - Tavazzi, Barbara
PY - 2013
Y1 - 2013
N2 - OBJECTIVES:: To assess the time course changes in N-acetylaspartate (NAA) and creatine (Cr) levels in the brain of athletes who suffered a sport-related concussion. PARTICIPANTS:: Eleven nonconsecutive athletes with concussive head injury and 11 sex- and age-matched control volunteers MAIN OUTCOME MEASURES:: At 3, 15, 30, and 45 days postinjury, athletes were examined by proton magnetic resonance spectroscopy for the determination of NAA, Cr, and choline (Cho) levels. Proton magnetic resonance spectroscopic data recorded for the control group were used for comparison. RESULTS:: Compared with controls (2.18 ± 0.19), athletes showed an increase in the NAA/Cr ratio at 3 (2.71 ± 0.16; P < .01) and 15 (2.54 ± 0.21; P < .01) days postconcussion, followed by a decrease and subsequent normalization at 30 (1.95 ± 0.16, P < .05) and 45 (2.17 ± 0.20; P < .05) days postconcussion. The NAA/Cho ratio decreased at 3, 15, and 30 days postinjury (P < .01 compared with controls), with no differences observed in controls at 45 days postconcussion. Compared with controls, significant increase in the Cho/Cr ratio after 3 (+33%, P < .01) and 15 (+31.5%, P < .01) days postinjury was observed whereas no differences were recorded at 30 and 45 days postinjury. CONCLUSIONS:: This cohort of athletes indicates that concussion may cause concomitant decrease in cerebral NAA and Cr levels. This provokes longer time for normalization of metabolism, as well as longer time for resolution of concussion-associated clinical symptoms.
AB - OBJECTIVES:: To assess the time course changes in N-acetylaspartate (NAA) and creatine (Cr) levels in the brain of athletes who suffered a sport-related concussion. PARTICIPANTS:: Eleven nonconsecutive athletes with concussive head injury and 11 sex- and age-matched control volunteers MAIN OUTCOME MEASURES:: At 3, 15, 30, and 45 days postinjury, athletes were examined by proton magnetic resonance spectroscopy for the determination of NAA, Cr, and choline (Cho) levels. Proton magnetic resonance spectroscopic data recorded for the control group were used for comparison. RESULTS:: Compared with controls (2.18 ± 0.19), athletes showed an increase in the NAA/Cr ratio at 3 (2.71 ± 0.16; P < .01) and 15 (2.54 ± 0.21; P < .01) days postconcussion, followed by a decrease and subsequent normalization at 30 (1.95 ± 0.16, P < .05) and 45 (2.17 ± 0.20; P < .05) days postconcussion. The NAA/Cho ratio decreased at 3, 15, and 30 days postinjury (P < .01 compared with controls), with no differences observed in controls at 45 days postconcussion. Compared with controls, significant increase in the Cho/Cr ratio after 3 (+33%, P < .01) and 15 (+31.5%, P < .01) days postinjury was observed whereas no differences were recorded at 30 and 45 days postinjury. CONCLUSIONS:: This cohort of athletes indicates that concussion may cause concomitant decrease in cerebral NAA and Cr levels. This provokes longer time for normalization of metabolism, as well as longer time for resolution of concussion-associated clinical symptoms.
KW - creatine, traumatic brain ijury, concussion, N-acetylaspartate
KW - creatine, traumatic brain ijury, concussion, N-acetylaspartate
UR - http://hdl.handle.net/10807/100254
U2 - 10.1097/HTR.0b013e3182795045
DO - 10.1097/HTR.0b013e3182795045
M3 - Article
SN - 0885-9701
VL - 2013
SP - 284
EP - 292
JO - Journal of Head Trauma Rehabilitation
JF - Journal of Head Trauma Rehabilitation
ER -