Declining prevalence of HIV-1 drug resistance in treatment-failing patients: a clinical cohort study.

Simona Di Giambenedetto, Paola Cattani, Giovanni Fadda, Roberto Cauda, Laura Bracciale, Manuela Colafigli, Alessandra Bacarelli, Andrea De Luca, Carmen Pinnetti, Mattia Prosperi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

OBJECTIVES: A major barrier to successful viral suppression in HIV type 1 (HIV-1)-infected individuals is the emergence of virus resistant to antiretroviral drugs. We explored the evolution of genotypic drug resistance prevalence in treatment-failing patients from 1999 to 2005 in a clinical cohort. PATIENTS AND METHODS: Prevalence of major International AIDS Society-USA HIV-1 drug resistance mutations was measured over calendar years in a population with treatment failure and undergoing resistance testing. Predictors of the presence of resistance mutations were analysed by logistic regression. RESULTS: Significant reductions of the prevalence of resistance to all three drug classes examined were observed. This was accompanied by a reduction in the proportion of treatment-failing patients. Independent predictors of drug resistance were the earlier calendar year, prior use of suboptimal nucleoside analogue therapy, male sex and higher CD4 levels at testing. CONCLUSIONS: In a single clinical cohort, we observed a decrease in the prevalence of resistance to all three examined antiretroviral drug classes over time. If this finding is confirmed in multicentre cohorts it may translate into reduced transmission of drug-resistant virus from treated patients.
Lingua originaleEnglish
pagine (da-a)835-839
Numero di pagine5
RivistaAntiviral Therapy
Stato di pubblicazionePubblicato - 2007

Keywords

  • Genotype
  • HAART
  • HIV

Fingerprint Entra nei temi di ricerca di 'Declining prevalence of HIV-1 drug resistance in treatment-failing patients: a clinical cohort study.'. Insieme formano una fingerprint unica.

Cita questo