Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe

Simona Di Giambenedetto, Andrea De Luca, Iuri Fanti, David Dunn, Maurizio Zazzi, Ricardo Camacho, Carlo Torti, Rolf Kaiser, Anders Sönnerborg, Francisco M. Codoñer, Kristel Van Laethem, Anne-Mieke Vandamme, Loveleen Bansi, Valeria Ghisetti, David A.M.C. Van De Vijver, David Asboe

Risultato della ricerca: Contributo in rivistaArticolo in rivista

47 Citazioni (Scopus)

Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaTHE JOURNAL OF INFECTIOUS DISEASES
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Drug Resistance Prevalence HIV-1

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