DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.

Maria Teresa Voso; Daniela Gumiero; Francesco D'Alo'; Francesco Guidi; Giovanna Rosaria Mansueto; Annalaura Di Febo; Giuseppina Massini; Maurizio Martini; Luigi Maria Larocca; Stefan Hohaus; Giuseppe Leone

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.

Maria Teresa Voso, Daniela Gumiero, Francesco D'Alo', Francesco Guidi, Giovanna Rosaria Mansueto, Annalaura Di Febo, Giuseppina Massini, Maurizio Martini, Luigi Maria Larocca, Stefan Hohaus, Giuseppe Leone

Risultato della ricerca: Contributo in rivista › Articolo in rivista

11 Citazioni (Scopus)

Abstract

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

Lingua originale	English
pagine (da-a)	1252-1256
Numero di pagine	5
Rivista	Haematologica
Volume	91
Stato di pubblicazione	Pubblicato - 2006

Keywords

DAP-kinase
Follicular Lymphoma
Methylation

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{76ba066d8b8247e7b30b67eecd035b17,

title = "DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.",

abstract = "We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).",

keywords = "DAP-kinase, Follicular Lymphoma, Methylation, DAP-kinase, Follicular Lymphoma, Methylation",

author = "Voso, {Maria Teresa} and Daniela Gumiero and Francesco D'Alo' and Francesco Guidi and Mansueto, {Giovanna Rosaria} and {Di Febo}, Annalaura and Giuseppina Massini and Maurizio Martini and Larocca, {Luigi Maria} and Stefan Hohaus and Giuseppe Leone",

year = "2006",

language = "English",

volume = "91",

pages = "1252--1256",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

}

TY - JOUR

T1 - DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.

AU - Voso, Maria Teresa

AU - Gumiero, Daniela

AU - D'Alo', Francesco

AU - Guidi, Francesco

AU - Mansueto, Giovanna Rosaria

AU - Di Febo, Annalaura

AU - Massini, Giuseppina

AU - Martini, Maurizio

AU - Larocca, Luigi Maria

AU - Hohaus, Stefan

AU - Leone, Giuseppe

PY - 2006

Y1 - 2006

N2 - We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

AB - We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

KW - DAP-kinase

KW - Follicular Lymphoma

KW - Methylation

KW - DAP-kinase

KW - Follicular Lymphoma

KW - Methylation

UR - http://hdl.handle.net/10807/6335

M3 - Article

SN - 0390-6078

VL - 91

SP - 1252

EP - 1256

JO - Haematologica

JF - Haematologica

ER -

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.

Abstract

Keywords

Altri file e collegamenti

Fingerprint

Cita questo