Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment

Rossella Maresca, Simone Varca, Federica Di Vincenzo, Maria Elena Ainora, Irene Mignini, Alfredo Papa, Franco Scaldaferri, Antonio Gasbarrini, Maria Cristina Giustiniani, Maria Assunta Zocco, Lucrezia Laterza

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

CMV infection is still a matter of concern in IBD patients, especially regarding the disease's relapse management. Why IBD patients, particularly those affected by ulcerative colitis, are more susceptible to CMV reactivation is not totally explained, although a weakened immune system could be the reason. Various techniques, ranging from serology to histology, can be employed to detect intestinal CMV infection; however, there is currently disagreement in the literature regarding the most effective diagnostic test. Furthermore, CMV involvement in steroid resistance has been broadly discussed, but whether CMV infection is a cause or consequence of the disease severity and, consequently, steroid refractoriness is still debated. Its potential contribution to the lack of response to advanced therapy and small molecules must be more valued and wholly explored. In this review, we look at the actual literature on CMV in IBD patients, and we suggest a pragmatic algorithm for clinical practice management of CMV infection.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Clinical Medicine
Volume13
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • CMV
  • Crohn’s
  • IBD
  • infections
  • ulcerative colitis

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