Cytomegalovirus Coinfection Is Associated With an Increased Risk of Severe Non-AIDS-Defining Events in a Large Cohort of HIV-Infected Patients

Andrea De Luca, Miriam Lichtner, Paola Cicconi, Serena Vita, Alessandro Cozzi-Lepri, Massimo Galli, Sergio Lo Caputo, Annalisa Saracino, Mariacristina Moioli, Franco Maggiolo, Giulia Marchetti, Vincenzo Vullo, Antonella D'Arminio Monforte

Risultato della ricerca: Contributo in rivistaArticolo in rivista

102 Citazioni (Scopus)

Abstract

Chronic cytomegalovirus (CMV) infection has been associated with immunosenescence and immunoactivation in the general population. In human immunodeficiency virus type 1 (HIV-1)-infected people, CMV coinfection, in addition to residual HIV replication and microbial translocation, has been proposed as a key factor in sustaining immune activation, even in individuals with a controlled HIV load.
Lingua originaleEnglish
pagine (da-a)178-186
Numero di pagine9
RivistaTHE JOURNAL OF INFECTIOUS DISEASES
Volume211
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • CMV infection
  • HIV infection
  • cardiovascular/cerebrovascular events
  • morbidity
  • mortality
  • severe non–AIDS-defining events

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