Cutaneous epithelioid cell histiocytoma: immunohistochemical and ultrastructural findings suggesting endothelial origin

Ketty Peris, L Manente, I Schmitt, Am Onetti, E Caracciolo, S. Chimenti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

13 Citazioni (Scopus)

Abstract

A 13-year-old boy presented with a polypoid nodule localized in the groin. Although the clinical and histopathological features corresponded to previously described diagnostic criteria of epithelioid cell histiocytoma, immunohistochemical and ultrastructural findings suggested vascular differentiation of the epithelioid cells. In particular, the immunohistochemical negativity of the epithelioid cell elements for Factor XIIIa failed to substantiate the previously forwarded hypothesis that this lesion represents a dendrocytoma. Instead, the presence of histiocytoid, vacuolated cells occasionally containing sparse red blood cells, positive staining for Factor VIII-related antigen, and ultrastructural evidence of endothelial characteristics in epithelioid neoplastic cells favor the hypothesis that "epithelioid cell histiocytoma" is of endothelial origin. We suggest the descriptive term cutaneous histiocytoid hemangioendothelioma for this lesion.
Lingua originaleEnglish
pagine (da-a)519-523
Numero di pagine5
RivistaAmerican Journal of Dermatopathology
Volume19
Stato di pubblicazionePubblicato - 1997

Keywords

  • Adolescent
  • Cell Differentiation
  • Cell Lineage
  • Endothelium, Vascular
  • Epithelioid Cells
  • Erythrocytes
  • Groin
  • Hemangioendothelioma
  • Histiocytes
  • Histiocytoma, Benign Fibrous
  • Humans
  • Immunohistochemistry
  • Male
  • Microscopy, Electron
  • Polyps
  • Skin Neoplasms
  • Transglutaminases
  • Tumor Markers, Biological
  • Vacuoles
  • von Willebrand Factor

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