Current evidence on the safety profile of NSAIDs for the treatment of PDA.

Costantino Romagnoli; Iliana Bersani; Serena Antonia Rubortone; Serafina Lacerenza; Maria Pia De Carolis

Current evidence on the safety profile of NSAIDs for the treatment of PDA.

Costantino Romagnoli, Iliana Bersani, Serena Antonia Rubortone, Serafina Lacerenza, Maria Pia De Carolis

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.

Lingua originale	English
pagine (da-a)	10-13
Numero di pagine	4
Rivista	THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Stato di pubblicazione	Pubblicato - 2011
Pubblicato esternamente	Sì

Keywords

treatment of PDA

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title = "Current evidence on the safety profile of NSAIDs for the treatment of PDA.",

abstract = "Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.",

keywords = "treatment of PDA, treatment of PDA",

author = "Costantino Romagnoli and Iliana Bersani and Rubortone, {Serena Antonia} and Serafina Lacerenza and {De Carolis}, {Maria Pia}",

year = "2011",

language = "English",

pages = "10--13",

journal = "THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE",

issn = "1476-7058",

publisher = "Parthenon Publishing:Richmond House, White Cross, South Road LA1 4QX United Kingdom:011 44 1524 585700, EMAIL: [email protected], INTERNET: http://www.parthpub.com, Fax: 011 44 1524 66882",

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TY - JOUR

T1 - Current evidence on the safety profile of NSAIDs for the treatment of PDA.

AU - Romagnoli, Costantino

AU - Bersani, Iliana

AU - Rubortone, Serena Antonia

AU - Lacerenza, Serafina

AU - De Carolis, Maria Pia

PY - 2011

Y1 - 2011

N2 - Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.

AB - Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants. Nonsteroidal anti-inflammatory drugs, especially Indomethacin and Ibuprofen, have been widely used for both prevention and treatment of PDA. Short-term efficacy of Indomethacin or Ibuprofen is equivalent, while Ibuprofen results show a higher safety profile. Ibuprofen is associated with fewer clinical gastrointestinal and renal side effects with respect to Indomethacin even if subclinical potential effects are reported. When administered as prophylaxis, Ibuprofen has no effects on prevention of intraventricular haemorrhage unlike Indomethacin. Considering the potential adverse effects of both these drugs, a careful monitoring during and after the treatment period is highly recommended.

KW - treatment of PDA

UR - http://hdl.handle.net/10807/23604

M3 - Article

SN - 1476-7058

SP - 10

EP - 13

JO - THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

JF - THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

ER -

Current evidence on the safety profile of NSAIDs for the treatment of PDA.

Abstract

Keywords

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