Local delivery of chemical agents for brain tumors has offered improved prognosis for patients with brain tumors in recent years. Agents of local delivery are highly desired for their ability to concentrate local, targeted therapeutic agents, including cytotoxic, antiangiogenic, and immunomodulatory agents in the precise location of neoplastic growth. The introduction of polymer drug delivery has offered one such form of local delivery, offering the all the benefits of general local delivery agents, including (1) controlled and (2) sustained release of chemotherapeutic agents over long periods of time, as well as (3) avoidance of the high systemic doses often related to systemic toxicities. Unlike other methods of local delivery, including catheter administration and convection-enhanced delivery (CED), polymer drugs do not rely, respectively, on mechanical function or pressure gradients.
- Alzheimer disease