Cultural and Genetic Approaches to Manage Aflatoxin Contamination: Recent Insights Provide Opportunities for Improved Control

Peter S. Ojiambo, Paola Battilani, Jeffrey W. Cary, Burt H. Blum, Ignazio Carbone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)


Aspergillus flavus is a morphologically complex species that can produce the group of polyketide derived carcinogenic and mutagenic secondary metabolites, aflatoxins, as well as other secondary metabolites such as cyclopiazonic acid and aflatrem. Aflatoxin causes aflatoxicosis when aflatoxins are ingested through contaminated food and feed. In addition, aflatoxin contamination is a major problem, from both an economic and health aspect, in developing countries, especially Asia and Africa, where cereals are an important food crops. Early measures for control of A. flavus infection and consequent aflatoxin contamination centered on creating unfavorable environments for the pathogen and destroying contaminated products. While development of atoxigenic (non-aflatoxin producing) strains of A. flavus as viable commercial biocontrol agents has marked a unique advance for control of aflatoxin contamination, particularly in Africa, new insights into the biology and sexuality of A. flavus are now providing opportunities to design improved atoxigenic strains for sustainable biocontrol of aflatoxin. Further, progress in the use of molecular technologies such as incorporation of antifungal genes in the host and host-induced gene silencing, is providing knowledge that could be harnessed to develop germplasm that is resistant to infection by A. flavus and aflatoxin contamination. This review summarizes the substantial progress that has been made to understand the biology of A. flavus and mitigate aflatoxin contamination in maize. Concepts developed to date can provide a basis for future research efforts on the sustainable management of aflatoxin contamination.
Lingua originaleEnglish
pagine (da-a)1024-1037
Numero di pagine14
Stato di pubblicazionePubblicato - 2018


  • Aspergillus flavus, aflòatoxins, management, review


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