Cryptides: latent peptides everywhere.

Federica Iavarone, Claudia Desiderio, Alberto Vitali, Irene Messana, Claudia Martelli, Massimo Castagnola, Tiziana Cabras

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Proteomic surveys with top-down platforms are today revealing thousands of naturally occurring fragments of bigger proteins. Some of them have not functional meaning because they derive from pathways responsible for protein degradation, but many have specific functions, often completely different from that one of the parent proteins. These peptides encrypted in the protein sequence are nowadays called cryptides. They are frequent in the animal and plant kingdoms and represent a new interesting -omic field of investigation. To point out how much widespread is their presence, we describe here the most studied cryptides from very common sources such as serum albumin, immunoglobulins, hemoglobin, and from saliva and milk proteins. Given its vastness, it is unfeasible to cover the topic exhaustively, therefore only several selected examples of cryptides from other sources are thereafter reported. Demanding is the development of new -omic platforms for the functional screening of new cryptides, which could provide suggestion for peptides and peptido-mimetics with variegate fields of application.
Lingua originaleEnglish
pagine (da-a)246-263
Numero di pagine18
RivistaCritical Reviews in Biochemistry and Molecular Biology
Volume2018
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • peptides
  • proteomics

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