CRANIAL IRRADIATION AND CEREBROSPINAL-FLUID LEVELS OF 6-MERCAPTOPURINE IN CHILDREN WITH ACUTE LEUKEMIA

Riccardo Riccardi; Anna Lasorella; Rosa Laura Tartaglia; Anna Shirley Riccardi; Tiziana Servidei; Renato Mastrangelo

doi:10.1007/BF02988860

CRANIAL IRRADIATION AND CEREBROSPINAL-FLUID LEVELS OF 6-MERCAPTOPURINE IN CHILDREN WITH ACUTE LEUKEMIA

Riccardo Riccardi, Anna Lasorella, Rosa Laura Tartaglia, Anna Shirley Riccardi, Tiziana Servidei, Renato Mastrangelo

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo in rivista

1 Citazioni (Scopus)

Abstract

We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial irradiation in order to evaluate a possible change in blood-brain barrier permeability to orally administered 6-mercaptopurine. Considerable interpatient variability has been observed in both plasma and cerebrospinal fluid 6-mercaptopurine levels. No statistical differences in t e 6-mercaptopurine cerebrospinal fluid levels under the three different conditions could be detected. Our data suggest that cranial irradiation does not significantly influence the cerebrospinal fluid levels.

Lingua originale	English
pagine (da-a)	95-98
Numero di pagine	4
Rivista	MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY
Volume	8
DOI	https://doi.org/10.1007/BF02988860
Stato di pubblicazione	Pubblicato - 1991

Keywords

6-MERCAPTOPURINE
childhood leukemia
cranial irradiation

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10.1007/BF02988860

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title = "CRANIAL IRRADIATION AND CEREBROSPINAL-FLUID LEVELS OF 6-MERCAPTOPURINE IN CHILDREN WITH ACUTE LEUKEMIA",

abstract = "We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial irradiation in order to evaluate a possible change in blood-brain barrier permeability to orally administered 6-mercaptopurine. Considerable interpatient variability has been observed in both plasma and cerebrospinal fluid 6-mercaptopurine levels. No statistical differences in t e 6-mercaptopurine cerebrospinal fluid levels under the three different conditions could be detected. Our data suggest that cranial irradiation does not significantly influence the cerebrospinal fluid levels.",

keywords = "6-MERCAPTOPURINE, childhood leukemia, cranial irradiation, 6-MERCAPTOPURINE, childhood leukemia, cranial irradiation",

author = "Riccardo Riccardi and Anna Lasorella and Tartaglia, {Rosa Laura} and Riccardi, {Anna Shirley} and Tiziana Servidei and Renato Mastrangelo",

year = "1991",

doi = "10.1007/BF02988860",

language = "English",

volume = "8",

pages = "95--98",

journal = "MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY",

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TY - JOUR

T1 - CRANIAL IRRADIATION AND CEREBROSPINAL-FLUID LEVELS OF 6-MERCAPTOPURINE IN CHILDREN WITH ACUTE LEUKEMIA

AU - Riccardi, Riccardo

AU - Lasorella, Anna

AU - Tartaglia, Rosa Laura

AU - Riccardi, Anna Shirley

AU - Servidei, Tiziana

AU - Mastrangelo, Renato

PY - 1991

Y1 - 1991

N2 - We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial irradiation in order to evaluate a possible change in blood-brain barrier permeability to orally administered 6-mercaptopurine. Considerable interpatient variability has been observed in both plasma and cerebrospinal fluid 6-mercaptopurine levels. No statistical differences in t e 6-mercaptopurine cerebrospinal fluid levels under the three different conditions could be detected. Our data suggest that cranial irradiation does not significantly influence the cerebrospinal fluid levels.

AB - We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial irradiation in order to evaluate a possible change in blood-brain barrier permeability to orally administered 6-mercaptopurine. Considerable interpatient variability has been observed in both plasma and cerebrospinal fluid 6-mercaptopurine levels. No statistical differences in t e 6-mercaptopurine cerebrospinal fluid levels under the three different conditions could be detected. Our data suggest that cranial irradiation does not significantly influence the cerebrospinal fluid levels.

KW - 6-MERCAPTOPURINE

KW - childhood leukemia

KW - cranial irradiation

KW - 6-MERCAPTOPURINE

KW - childhood leukemia

KW - cranial irradiation

UR - http://hdl.handle.net/10807/16314

U2 - 10.1007/BF02988860

DO - 10.1007/BF02988860

M3 - Article

VL - 8

SP - 95

EP - 98

JO - MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY

JF - MEDICAL ONCOLOGY AND TUMOR PHARMACOTHERAPY

ER -

CRANIAL IRRADIATION AND CEREBROSPINAL-FLUID LEVELS OF 6-MERCAPTOPURINE IN CHILDREN WITH ACUTE LEUKEMIA

Abstract

Keywords

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