Abstract
CpG oligodeoxynucleotides have been previously shown to enhance antimycobacterial response in
human monocytes/macrophages. The present study reports evidences showing the capability of CpG oligodeoxynucleotides
to induce (i) host phospholipase D (PLD) activation, (ii) PLD dependent reactive oxygen
intermediate production, (iii) PLD dependent phagolysosome maturation and (iv) PLD dependent
intracellular mycobacterial killing in type II alveolar epithelial cells. These are the first evidences showing
that alveolar epithelial cells may represent efficient effecter cells during primary innate antimycobacterial
immune response.
Lingua originale | English |
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pagine (da-a) | 1-4 |
Numero di pagine | 4 |
Rivista | Cellular Immunology |
Volume | 259 |
Stato di pubblicazione | Pubblicato - 2009 |
Keywords
- lysosome