COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel

Cecilia Napodano, Krizia Pocino, Annunziata Stefanile, Mariapaola Marino, Luca Miele, Francesca Gulli, Valerio Basile, Franco Pandolfi, Antonio Gasbarrini, Gian Ludovico Rapaccini, Umberto Basile

Risultato della ricerca: Contributo in rivistaArticolo in rivista


In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
Lingua originaleEnglish
pagine (da-a)e12977-N/A
RivistaScandinavian Journal of Immunology
Stato di pubblicazionePubblicato - 2021


  • Antiviral Agents
  • COVID-19
  • Cytokine Release Syndrome
  • Cytokines
  • Hepatocytes
  • Humans
  • Liver
  • Liver Diseases
  • Pandemics
  • SARS-CoV-2
  • cytokine storm syndrome
  • liver diseases
  • liver transplantation


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