TY - JOUR
T1 - Could we use a lower dose of rituximab to treat rheumatoid arthritis in clinical practice: Pros and cons?
AU - Ferraccioli, Gianfranco
AU - Tolusso, Barbara
AU - Gremese, Elisa
PY - 2016
Y1 - 2016
N2 - The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has been shown that rituximab 500 mg twice, performs as well as 1 g twice, 2 weeks apart, in terms of the American College of Rheumatology (ACR)20 and ACR50, but not the ACR70. The choice should always be made after considering that the IMAGE trial has demonstrated similar radiographic progression after the first 6 months, but with less control, with low-dose rituximab in the first 6 months. A possible alternative can be hypothesized.
AB - The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has been shown that rituximab 500 mg twice, performs as well as 1 g twice, 2 weeks apart, in terms of the American College of Rheumatology (ACR)20 and ACR50, but not the ACR70. The choice should always be made after considering that the IMAGE trial has demonstrated similar radiographic progression after the first 6 months, but with less control, with low-dose rituximab in the first 6 months. A possible alternative can be hypothesized.
KW - High dose
KW - Immunology
KW - Immunology and Allergy
KW - Low dose
KW - Peripheral B cell depletion
KW - Rheumatology
KW - Rituximab
KW - Synovial tissue B cell depletion
KW - High dose
KW - Immunology
KW - Immunology and Allergy
KW - Low dose
KW - Peripheral B cell depletion
KW - Rheumatology
KW - Rituximab
KW - Synovial tissue B cell depletion
UR - http://hdl.handle.net/10807/94041
UR - http://arthritis-research.com/
U2 - 10.1186/s13075-016-1022-1
DO - 10.1186/s13075-016-1022-1
M3 - Article
SN - 1478-6354
VL - 18
SP - 126-N/A
JO - ARTHRITIS RESEARCH & THERAPY
JF - ARTHRITIS RESEARCH & THERAPY
ER -