Could direct stenting reduce no-reflow in acute coronary syndromes? A randomized pilot study

Francesco Burzotta, Rémi Sabatier, Martial Hamon, Quan Ming Zhao, Emmanuel Lecluse, Benoit Valette, Gilles Grollier

Risultato della ricerca: Contributo in rivistaArticolo in rivista

36 Citazioni (Scopus)


Objectives: Recently, direct stenting has been shown in retrospective and randomized studies to be feasible and safe in highly selected patients, with a potential interest to reduce the cost of the procedure and the rate of no-reflow. This randomized pilot study was designed to compare the incidence of no-reflow after direct stenting or conventional stenting after balloon predilation in acute coronary syndrome-related lesions. Methods anal Results: Between December 1998 and October 1999, 130 patients in our center with acute coronary syndromes were included in this study and randomized in 2 groups. In group A (n = 65), direct stent implantation was performed without balloon predilation. In group B (n = 65), conventional balloon predilation was carried out before stent implantation. Baseline clinical and angiographic characteristics before the procedure were similar in the 2 groups of patients. No-reflow was observed in 7.7% after direct stenting and in 6.1% after conventional stent implantation (P = not significant). The immediate clinical success rate was similar in the 2 groups. Among the procedural data, only duration of the procedure (shorter in the direct stenting group), the number of balloons used, and the quantity of contrast agent (lower in the direct stenting group) were significantly different between the 2 groups (P <. 05). The 6-month clinical outcome was similar in the 2 groups. Conclusion: This randomized study confirms the promising results of previous studies that show the feasibility and the safety of direct coronary stenting in highly selected acute coronary syndrome-related lesions. The major impact of this strategy is the improvement of the cost-benefit ratio, with no major influence on the acute complications and especially on the occurrence of no-reflow in this high-risk population.
Lingua originaleEnglish
pagine (da-a)1027-1032
Numero di pagine6
RivistaAmerican Heart Journal
Stato di pubblicazionePubblicato - 2002


  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Angina, Unstable
  • Angioplasty, Balloon, Coronary
  • Coronary Angiography
  • Coronary Circulation
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Patient Selection
  • Pilot Projects
  • Safety
  • Statistics as Topic
  • Stents
  • Syndrome


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