Correlations between peripheral blood mononuclear cell production of BDNF, TNF-alpha, IL-6, IL-10 and cognitive performances in multiple sclerosis patients

Guido Gainotti, Camillo Marra, Massimiliano Zinno, Davide Quaranta, Viviana Nociti, Giovanni Frisullo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

78 Citazioni (Scopus)

Abstract

The aim of this study was to investigate the role of Brain Derived Neurotrophic Factor (BDNF) and inflammatory factors in the development of cognitive dysfunctions in Multiple Sclerosis (MS). We correlated peripheral blood mononuclear cell (PBMC) production of BDNF, Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin (IL)-6 and IL-10 with performances on specific neuropsychological tasks in a selected series of MS patients. We studied a sample of 30 patients with relapsing-remitting (RR)MS, segregated by gender and matched for age, education, disease duration, type of immunomodulating therapy, degree of disability and overall cognitive status. We found that low BDNF levels were correlated with increased time of execution on a divided attention and visual scanning task whereas high levels of IL-6 were correlated with low Mini Mental State Examination scores. We did not observe any significant correlations between IL-10, TNF-alpha levels and cognitive performances in our patients. In conclusion our study shows a correlation between low BDNF and high IL-6 production by PBMCs and poorer performances in cognitive tasks in RRMS patients suggesting a possible role of these factors in cognitive impairment in MS.
Lingua originaleEnglish
pagine (da-a)1106-1112
Numero di pagine7
RivistaJournal of Neuroscience Research
Volume88
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Adult
  • Biological Markers
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognition Disorders
  • Cohort Studies
  • Cytokines
  • Encephalitis
  • Female
  • Humans
  • Interleukin-10
  • Interleukin-6
  • Leukocytes, Mononuclear
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting
  • Nerve Growth Factors
  • Neuropsychological Tests
  • Statistics as Topic
  • Tumor Necrosis Factor-alpha

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