Correlation of sonographic characteristics and pathomorphological findings in cases of early-stage cervical cancer: preliminary results.

A Gaurilcikas, D Vaitkiene, Antonia Carla Testa, R Maciuleviciene, S Kajenas, A Cizauskas, D Simanaviciute, E Svedas, Rj Nadisauskiene, A Inciura, K. Levisauskas

Risultato della ricerca: Contributo in rivistaContributo a convegnopeer review


Objectives: To correlate the sonographic two-dimensional (2D) gray-scale features with pathological findings in early-stage invasive cervical cancer. Methods: Eighteen patients with biopsy-confirmed invasive cervical carcinoma (stages IB1 IIA according to FIGO staging) who underwent surgery were enrolled in the study. Transvaginal 2D gray-scale sonography was performed in all of them at the Hospital of Kaunas University of Medicine prior to hysterectomy. The largest diameters of tumor mass, tumor shape, tumor area, as well as the deepest cervical stromal invasion and the largest thickness of tumorfree cervical stroma in sagittal and axial planes were correlated with their pathomorphological equivalents using Pearson correlation coefficients. Toshiba NICE and Canvas X Scientific Edition software packages were employed for the analysis and correlation of sonographic and pathomorphological images. The interobserver variability was evaluated by having two blinded sonologists interpret each examination and calculating kappa statistics. The intraobserver variability was assayed in nine patients at 24-h intervals. Results: At 2D gray-scale analysis 15 patients (83%) showed detectable tumor masses. The largest diameters of the tumor mass (maximum length, depth and width) measured at sonographic and pathomorphological examinations correlated well (R = 0.87, R = 0.89 and R = 0.76, respectively). The largest tumor area measured in both sagittal and axial planes also showed a strong correlation (R = 0.78 and R = 0.84, respectively). Poor correlation was seen in the deepest cervical stromal invasion (R = 0.14). A discrepancy of more than 10% of the tumor shape in the sagittal plane seen during sonography and pathomorphological examination occurred in seven cases (47%). Conclusions: Two-dimensional gray-scale sonography is accurate in the assessment of early-stage cervical cancer. This method should be considered in all patients with early-stage cervical cancer scheduled for radical treatment.
Lingua originaleEnglish
pagine (da-a)407-408
Numero di pagine2
Stato di pubblicazionePubblicato - 2007
Evento17th World Congress on Ultrasound in Obstetrics and Gynecology - Firenze
Durata: 7 ott 200711 ott 2007


  • Correlation sonographic pathomorphological
  • early stage cervical cancer


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