Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.

Mario Tumbarello; Angelo Maria Minnella; Giulio Ventura; Roberto Cauda; Evelina Tacconelli; Giancarlo Scoppettuolo; Ricardo Rabagliati

Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.

Mario Tumbarello, Angelo Maria Minnella, Giulio Ventura, Roberto Cauda, Evelina Tacconelli, Giancarlo Scoppettuolo, Ricardo Rabagliati

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

6 Citazioni (Scopus)

Abstract

In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.

Lingua originale	English
pagine (da-a)	114-117
Numero di pagine	4
Rivista	EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Stato di pubblicazione	Pubblicato - 2003

Keywords

Cidofovir
HIV infection
Uveitis

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title = "Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.",

abstract = "In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.",

keywords = "Cidofovir, HIV infection, Uveitis, Cidofovir, HIV infection, Uveitis",

author = "Mario Tumbarello and Minnella, {Angelo Maria} and Giulio Ventura and Roberto Cauda and Evelina Tacconelli and Giancarlo Scoppettuolo and Ricardo Rabagliati",

year = "2003",

language = "English",

pages = "114--117",

journal = "EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES",

issn = "0934-9723",

publisher = "Editore attuale: SPRINGER, 233 SPRING STREET, NEW YORK, USA, NY, 10013 Precedente MMV Medizin Verlag:Postfach 801246, Neumarkter Street 18, D 81664 Munich Germany:011 49 89 431890, EMAIL: andrea.roethig@berterlsmann.de, INTERNET: http://www.mmw.de, Fax: 011 49 89 48189633",

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Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART. / Tumbarello, Mario; Minnella, Angelo Maria ; Ventura, Giulio ; Cauda, Roberto; Tacconelli, Evelina; Scoppettuolo, Giancarlo; Rabagliati, Ricardo.

In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2003, pag. 114-117.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.

AU - Tumbarello, Mario

AU - Minnella, Angelo Maria

AU - Ventura, Giulio

AU - Cauda, Roberto

AU - Tacconelli, Evelina

AU - Scoppettuolo, Giancarlo

AU - Rabagliati, Ricardo

PY - 2003

Y1 - 2003

N2 - In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.

AB - In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.

KW - Cidofovir

KW - HIV infection

KW - Uveitis

KW - Cidofovir

KW - HIV infection

KW - Uveitis

UR - http://hdl.handle.net/10807/12779

M3 - Article

SP - 114

EP - 117

JO - EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

JF - EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

SN - 0934-9723

ER -