Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.

Mario Tumbarello, Angelo Maria Minnella, Giulio Ventura, Roberto Cauda, Evelina Tacconelli, Giancarlo Scoppettuolo, Ricardo Rabagliati

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

6 Citazioni (Scopus)

Abstract

In order to elucidate the factors related to the development of cidofovir-associated uveitis in AIDS patients receiving highly active antiretroviral therapy, the characteristics of 17 AIDS patients with Cytomegalovirus retinitis ( n=10) or progressive multifocal leukoencephalopathy ( n=7) treated with intravenous cidofovir were evaluated. Six cases of cidofovir-associated uveitis occurred among the patients with retinitis. No cases were detected among the patients with progressive multifocal leukoencephalopathy. Stepwise linear regression analysis revealed a significantly higher HIV-viremia level ( P=0.01) and a significantly lower CD4+ cell count ( P=0.009) among cases at the time of uveitis onset in comparison with patients who did not develop uveitis. Thus, cidofovir-associated uveitis seems to occur more frequently in AIDS patients with retinitis in whom highly active antiretroviral therapy fails to restore immunity.
Lingua originaleEnglish
pagine (da-a)114-117
Numero di pagine4
RivistaEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Stato di pubblicazionePubblicato - 2003

Keywords

  • Cidofovir
  • HIV infection
  • Uveitis

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