TY - JOUR
T1 - Coronary microvascular dysfunction: an update
AU - Crea, Filippo
AU - Camici, Paolo G.
AU - Merz, Cathleen Noel Bairey
PY - 2013
Y1 - 2013
N2 - Many patients undergoing coronary angiography because of chest pain syndromes, believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries, are found to have normal angiograms. In the past two decades, a number of studies have reported that abnormalities in the function and structure of the coronary microcirculation may occur in patients without obstructive atherosclerosis, but with risk factors or with myocardial diseases as well as in patients with obstructive atherosclerosis; furthermore, coronary microvascular dysfunction (CMD) can be iatrogenic. In some instances, CMD represents an epiphenomenon, whereas in others it is an important marker of risk or may even contribute to the pathogenesis of cardiovascular and myocardial diseases, thus becoming a therapeutic target. This review article provides an update on the clinical relevance of CMD in different clinical settings and also the implications for therapy.
AB - Many patients undergoing coronary angiography because of chest pain syndromes, believed to be indicative of obstructive atherosclerosis of the epicardial coronary arteries, are found to have normal angiograms. In the past two decades, a number of studies have reported that abnormalities in the function and structure of the coronary microcirculation may occur in patients without obstructive atherosclerosis, but with risk factors or with myocardial diseases as well as in patients with obstructive atherosclerosis; furthermore, coronary microvascular dysfunction (CMD) can be iatrogenic. In some instances, CMD represents an epiphenomenon, whereas in others it is an important marker of risk or may even contribute to the pathogenesis of cardiovascular and myocardial diseases, thus becoming a therapeutic target. This review article provides an update on the clinical relevance of CMD in different clinical settings and also the implications for therapy.
KW - Acute coronary syndromes
KW - Coronary microvascular dysfunction
KW - Coronary microvascular obstruction
KW - Myocardial diseases
KW - Stable angina
KW - Acute coronary syndromes
KW - Coronary microvascular dysfunction
KW - Coronary microvascular obstruction
KW - Myocardial diseases
KW - Stable angina
UR - http://hdl.handle.net/10807/51125
U2 - 10.1093/eurheartj/eht513
DO - 10.1093/eurheartj/eht513
M3 - Article
SN - 1522-9645
SP - N/A-N/A
JO - European Heart Journal
JF - European Heart Journal
ER -