Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes

Giulio Russo; Daniela Pedicino; Claudio Chiastra; Ramona Vinci; Maurizio Lodi Rizzini; Lorenzo Genuardi; Mohammad Sarraf; Alessia d'Aiello; Marco Bologna; Cristina Aurigemma; Alice Bonanni; Antonio Bellantoni; Fabrizio D'Ascenzo; Pellegrino Ciampi; Aniello Zambrano; Luca Mainardi; Myriana Ponzo; Anna Severino; Carlo Trani; Massimo Massetti; Diego Gallo; Francesco Migliavacca; Francesco Maisano; Amir Lerman; Umberto Morbiducci; Francesco Burzotta; Filippo Crea; Giovanna Liuzzo

doi:10.1016/j.ijcard.2022.10.139

Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes

Giulio Russo
, Daniela Pedicino^*
, Claudio Chiastra
, Ramona Vinci
, Maurizio Lodi Rizzini
, Lorenzo Genuardi
, Mohammad Sarraf
, Alessia d'Aiello
, Marco Bologna
, Cristina Aurigemma
, Alice Bonanni
, Antonio Bellantoni
, Fabrizio D'Ascenzo
, Pellegrino Ciampi
, Aniello Zambrano
, Luca Mainardi
, Myriana Ponzo
, Anna Severino
, Carlo Trani
, Massimo Massetti

Diego Gallo, Francesco Migliavacca, Francesco Maisano, Amir Lerman, Umberto Morbiducci, Francesco Burzotta, Filippo Crea, Giovanna Liuzzo

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Wall shear stress (WSS) is involved in coronary artery plaque pathological mechanisms and modulation of gene expression. This study aims to provide a comprehensive haemodynamic and biological description of unstable (intact-fibrous-cap, IFC, and ruptured-fibrous-cap, RFC) and stable (chronic coronary syndrome, CCS) plaques and investigate any correlation between WSS and molecular pathways.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	International Journal of Cardiology
Numero di pubblicazione	22
DOI	https://doi.org/10.1016/j.ijcard.2022.10.139
Stato di pubblicazione	Pubblicato - 2022

All Science Journal Classification (ASJC) codes

Cardiologia e Medicina Cardiovascolare

Keywords

Acute coronary syndrome
Computational fluid dynamics
Personalized medicine
Plaque erosion
Plaque rupture
Shear stress
Vulnerable plaque

Accesso al documento

10.1016/j.ijcard.2022.10.139

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Russo, G., Pedicino, D., Chiastra, C., Vinci, R., Lodi Rizzini, M., Genuardi, L., Sarraf, M., d'Aiello, A., Bologna, M., Aurigemma, C., Bonanni, A., Bellantoni, A., D'Ascenzo, F., Ciampi, P., Zambrano, A., Mainardi, L., Ponzo, M., Severino, A., Trani, C., ... Liuzzo, G. (2022). Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes. International Journal of Cardiology, (22), N/A-N/A. https://doi.org/10.1016/j.ijcard.2022.10.139

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title = "Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes",

abstract = "Wall shear stress (WSS) is involved in coronary artery plaque pathological mechanisms and modulation of gene expression. This study aims to provide a comprehensive haemodynamic and biological description of unstable (intact-fibrous-cap, IFC, and ruptured-fibrous-cap, RFC) and stable (chronic coronary syndrome, CCS) plaques and investigate any correlation between WSS and molecular pathways.",

keywords = "Acute coronary syndrome, Computational fluid dynamics, Personalized medicine, Plaque erosion, Plaque rupture, Shear stress, Vulnerable plaque, Acute coronary syndrome, Computational fluid dynamics, Personalized medicine, Plaque erosion, Plaque rupture, Shear stress, Vulnerable plaque",

author = "Giulio Russo and Daniela Pedicino and Claudio Chiastra and Ramona Vinci and \{Lodi Rizzini\}, Maurizio and Lorenzo Genuardi and Mohammad Sarraf and Alessia d'Aiello and Marco Bologna and Cristina Aurigemma and Alice Bonanni and Antonio Bellantoni and Fabrizio D'Ascenzo and Pellegrino Ciampi and Aniello Zambrano and Luca Mainardi and Myriana Ponzo and Anna Severino and Carlo Trani and Massimo Massetti and Diego Gallo and Francesco Migliavacca and Francesco Maisano and Amir Lerman and Umberto Morbiducci and Francesco Burzotta and Filippo Crea and Giovanna Liuzzo",

year = "2022",

doi = "10.1016/j.ijcard.2022.10.139",

language = "English",

pages = "N/A--N/A",

journal = "International Journal of Cardiology",

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Russo, G, Pedicino, D, Chiastra, C, Vinci, R, Lodi Rizzini, M, Genuardi, L, Sarraf, M, d'Aiello, A, Bologna, M, Aurigemma, C, Bonanni, A, Bellantoni, A, D'Ascenzo, F, Ciampi, P, Zambrano, A, Mainardi, L, Ponzo, M, Severino, A, Trani, C , Massetti, M, Gallo, D, Migliavacca, F, Maisano, F, Lerman, A, Morbiducci, U, Burzotta, F, Crea, F & Liuzzo, G 2022, 'Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes', International Journal of Cardiology, n. 22, pagg. N/A-N/A. https://doi.org/10.1016/j.ijcard.2022.10.139

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AU - Russo, Giulio

AU - Pedicino, Daniela

AU - Chiastra, Claudio

AU - Vinci, Ramona

AU - Lodi Rizzini, Maurizio

AU - Genuardi, Lorenzo

AU - Sarraf, Mohammad

AU - d'Aiello, Alessia

AU - Bologna, Marco

AU - Aurigemma, Cristina

AU - Bonanni, Alice

AU - Bellantoni, Antonio

AU - D'Ascenzo, Fabrizio

AU - Ciampi, Pellegrino

AU - Zambrano, Aniello

AU - Mainardi, Luca

AU - Ponzo, Myriana

AU - Severino, Anna

AU - Trani, Carlo

AU - Massetti, Massimo

AU - Gallo, Diego

AU - Migliavacca, Francesco

AU - Maisano, Francesco

AU - Lerman, Amir

AU - Morbiducci, Umberto

AU - Burzotta, Francesco

AU - Crea, Filippo

AU - Liuzzo, Giovanna

PY - 2022

Y1 - 2022

N2 - Wall shear stress (WSS) is involved in coronary artery plaque pathological mechanisms and modulation of gene expression. This study aims to provide a comprehensive haemodynamic and biological description of unstable (intact-fibrous-cap, IFC, and ruptured-fibrous-cap, RFC) and stable (chronic coronary syndrome, CCS) plaques and investigate any correlation between WSS and molecular pathways.

AB - Wall shear stress (WSS) is involved in coronary artery plaque pathological mechanisms and modulation of gene expression. This study aims to provide a comprehensive haemodynamic and biological description of unstable (intact-fibrous-cap, IFC, and ruptured-fibrous-cap, RFC) and stable (chronic coronary syndrome, CCS) plaques and investigate any correlation between WSS and molecular pathways.

KW - Acute coronary syndrome

KW - Computational fluid dynamics

KW - Personalized medicine

KW - Plaque erosion

KW - Plaque rupture

KW - Shear stress

KW - Vulnerable plaque

KW - Acute coronary syndrome

KW - Computational fluid dynamics

KW - Personalized medicine

KW - Plaque erosion

KW - Plaque rupture

KW - Shear stress

KW - Vulnerable plaque

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U2 - 10.1016/j.ijcard.2022.10.139

DO - 10.1016/j.ijcard.2022.10.139

M3 - Article

SN - 0167-5273

SP - N/A-N/A

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 22

ER -

Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

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