CORD-BLOOD MONONUCLEAR CELL RESPONSIVENESS TO BETA-LACTOGLOBULIN - T-CELL ACTIVITY IN ATOPY-PRONE AND NON-ATOPY-PRONE NEWBORNS

Marco Piastra, Giovambattista Pani, Francesco Ria, Achille Stabile, Massimo Castagnola, G Fioravanti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

74 Citazioni (Scopus)

Abstract

We have studied the T-cell-mediated response to the major allergen of cow's milk, in a group of newborns at risk of developing cow's milk allergy, and in a control group. Before any atopic status has developed, we observe beta-lactoglobulin-specific proliferation only in the group at risk for food-related allergies. In this group, the capability to proliferate is not due to placental transmission of `factors' from allergic mothers. The recognition of the tested beta-lactoglobulin peptides does not show major differences between the responder and nonresponder populations. In the responder population, the response to p145-161 appears linked to a primary response to ovalbumin, another frequent food allergen. On the basis of our findings, we propose a model in which development of allergic diseases is linked to an alteration of T-cell activation through the engagement by the antigen; the HLA phenotype determines the allergen(s) involved, and other genetic or environmental factors dictate the clinical characteristics of the disease.
Lingua originaleEnglish
pagine (da-a)358-365
Numero di pagine8
RivistaInternational Archives of Allergy and Immunology
Volume104
Stato di pubblicazionePubblicato - 1994

Keywords

  • MONONUCLEAR

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