TY - JOUR
T1 - CORD-BLOOD MONONUCLEAR CELL RESPONSIVENESS TO BETA-LACTOGLOBULIN - T-CELL ACTIVITY IN ATOPY-PRONE AND NON-ATOPY-PRONE NEWBORNS
AU - Piastra, Marco
AU - Pani, Giovambattista
AU - Ria, Francesco
AU - Stabile, Achille
AU - Castagnola, Massimo
AU - Fioravanti, G
PY - 1994
Y1 - 1994
N2 - We have studied the T-cell-mediated response to the major allergen of
cow's milk, in a group of newborns at risk of developing cow's milk
allergy, and in a control group. Before any atopic status has developed,
we observe beta-lactoglobulin-specific proliferation only in the group
at risk for food-related allergies. In this group, the capability to
proliferate is not due to placental transmission of `factors' from
allergic mothers. The recognition of the tested beta-lactoglobulin
peptides does not show major differences between the responder and
nonresponder populations. In the responder population, the response to
p145-161 appears linked to a primary response to ovalbumin, another
frequent food allergen. On the basis of our findings, we propose a model
in which development of allergic diseases is linked to an alteration of
T-cell activation through the engagement by the antigen; the HLA
phenotype determines the allergen(s) involved, and other genetic or
environmental factors dictate the clinical characteristics of the
disease.
AB - We have studied the T-cell-mediated response to the major allergen of
cow's milk, in a group of newborns at risk of developing cow's milk
allergy, and in a control group. Before any atopic status has developed,
we observe beta-lactoglobulin-specific proliferation only in the group
at risk for food-related allergies. In this group, the capability to
proliferate is not due to placental transmission of `factors' from
allergic mothers. The recognition of the tested beta-lactoglobulin
peptides does not show major differences between the responder and
nonresponder populations. In the responder population, the response to
p145-161 appears linked to a primary response to ovalbumin, another
frequent food allergen. On the basis of our findings, we propose a model
in which development of allergic diseases is linked to an alteration of
T-cell activation through the engagement by the antigen; the HLA
phenotype determines the allergen(s) involved, and other genetic or
environmental factors dictate the clinical characteristics of the
disease.
KW - MONONUCLEAR
KW - MONONUCLEAR
UR - http://hdl.handle.net/10807/23685
M3 - Article
VL - 104
SP - 358
EP - 365
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
ER -