Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins

Ruggero De Maria Marchiano, Giorgio Stassi, Diana Di Liberto, Matilde Todaro, Ann Zeuner, Lucia Ricci-Vitiani, Antonella Stoppacciaro, Luigi Ruco, Felicia Farina, Giovanni Zummo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

129 Citazioni (Scopus)

Abstract

After autoimmune inflammation, interactions between CD95 and its ligand (CD95L) mediate thyrocyte destruction in Hashimoto's thyroiditis (HT). Conversely, thyroid autoimmune processes that lead to Graves' disease (GD) result in autoantibody-mediated thyrotropin receptor stimulation without thyrocyte depletion. We found that GD thyrocytes expressed CD95 and CD95L in a similar manner to HT thyrocytes, but did not undergo CD95-induced apoptosis either in vivo or in vitro. This pattern was due to the differential production of TH1 and TH2 cytokines. Interferon γ promoted caspase up-regulation and CD95-induced apoptosis in HT thyrocytes, whereas interleukin 4 and interleukin 10 protected GD thyrocytes by potent up-regulation of cFLIP and Bcl-xL, which prevented CD95-induced apoptosis in sensitized thyrocytes. Thus, modulation of apoptosis-related proteins by TH1 andTH2 cytokines controls thyrocyte survival in thyroid autoimmunity.
Lingua originaleEnglish
pagine (da-a)483-488
Numero di pagine6
RivistaNature Immunology
Volume1
Stato di pubblicazionePubblicato - 2000

Keywords

  • Immunology

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