Control and impairment of immune privilege in the testis and in semen

Alessio D'Alessio, Luigi Gandini, A Filippini, A Riccioli, F Padula, P Lauretti, P De Cesaris, A Lenzi, E. Ziparo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

81 Citazioni (Scopus)

Abstract

It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment of immunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppressive molecules by Sertoli cells; and the Fas system as regulator of immunological homeostasis in both physiological and pathological conditions. Cytokine-induced up-regulation of Fas as well as of integrin ligands, which are known to be specific binding molecules for lymphocytes on the Sertoli cell surface, indicates that the 'nursing' cells of seminiferous epithelium might be important in the impairment of immune privilege, causing autoimmune orchitis. In addition, the soluble form of Fas-ligand protein present in the seminal plasma of infertile patients might suggest a role for this immunomodulatory protein in male infertility. Finally, an understanding of the mechanisms underlying immune privilege in the testis and in semen might help to clarify how cells expressing 'non-self' antigens (such as male gametes) can escape the immune system in both the male and female genital tracts.
Lingua originaleEnglish
pagine (da-a)444-449
Numero di pagine6
RivistaHuman Reproduction Update
Volume7
Stato di pubblicazionePubblicato - 2001

Keywords

  • Fertilization in Vitro
  • Humans
  • Immunity
  • Male
  • Reproduction
  • Reproductive Techniques
  • Spermatozoa

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