Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process

Sandro Cacchi; Giancarlo Fabrizi; Antonella Goggiamani; Antonia Iazzetti

doi:10.1021/acs.orglett.6b01720

Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process

Sandro Cacchi, Giancarlo Fabrizi, Antonella Goggiamani, Antonia Iazzetti

University of Rome La Sapienza

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.

Lingua originale	English
pagine (da-a)	3511-3513
Numero di pagine	3
Rivista	Organic Letters
Volume	18
DOI	https://doi.org/10.1021/acs.orglett.6b01720
Stato di pubblicazione	Pubblicato - 2016

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title = "Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process",

abstract = "The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.",

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T1 - Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process

AU - Cacchi, Sandro

AU - Fabrizi, Giancarlo

AU - Goggiamani, Antonella

AU - Iazzetti, Antonia

PY - 2016

Y1 - 2016

N2 - The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.

AB - The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.

KW - inglese

UR - http://hdl.handle.net/10807/200521

U2 - 10.1021/acs.orglett.6b01720

DO - 10.1021/acs.orglett.6b01720

M3 - Article

SN - 1523-7060

VL - 18

SP - 3511

EP - 3513

JO - Organic Letters

JF - Organic Letters

ER -

Construction of the 1,5-Benzodiazepine Skeleton from o-Phenylendiamine and Propargylic Alcohols via a Domino Gold-Catalyzed Hydroamination/Cyclization Process

Abstract

Keywords

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