Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts

Mariapaola Marino, Carlo Provenzano, Flavia Scuderi, Emanuela Bartoccioni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

34 Citazioni (Scopus)

Abstract

We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V.
Lingua originaleEnglish
pagine (da-a)94-101
Numero di pagine8
RivistaJournal of Neuroimmunology
Volume116
DOI
Stato di pubblicazionePubblicato - 2001

Keywords

  • Cells, Cultured
  • Cytokine
  • Cytokines
  • DNA vaccination
  • Flow Cytometry
  • Gene therapy
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Humans
  • Inflammatory myopathies
  • Intercellular Adhesion Molecule-1
  • MHC
  • Muscle, Skeletal
  • Myoblast
  • RNA, Messenger

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