Abstract
We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 94-101 |
| Numero di pagine | 8 |
| Rivista | Journal of Neuroimmunology |
| Volume | 116 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2001 |
Keywords
- Cells, Cultured
- Cytokine
- Cytokines
- DNA vaccination
- Flow Cytometry
- Gene therapy
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Inflammatory myopathies
- Intercellular Adhesion Molecule-1
- MHC
- Muscle, Skeletal
- Myoblast
- RNA, Messenger
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