TY - JOUR
T1 - Considering gut microbiota disturbance in the management of Helicobacter pylori infection
AU - Lopetuso, Loris Riccardo
AU - Napoli, Marco
AU - Rizzatti, Gianenrico
AU - Scaldaferri, Franco
AU - Franceschi, Francesco
AU - Gasbarrini, Antonio
PY - 2018
Y1 - 2018
N2 - Introduction: Helicobacter pylori (Hp) infection produces drastic changes in the gastric microenvironment, which, in turn, influence the gastric microbiota composition and might be correlated with large intestinal microbiota changes. This excellent perturbing actor could trigger important modifications in the homeostatic functions exerted by gut commensals leading to a new gastrointestinal balance. At the same time, the therapeutic strategies used to eradicate Hp can modulate this physiological symbiosis, but can be also conversely affected by its properties. Area covered: The purpose of this review is to explore the reciprocal interplay between Hp infection and gut microbiota and analyze how microbial changes can influence the management of Hp eradication therapies. Expert commentary: While many studies have described Hp-dependent gut microbiota alterations, their clinical implications are only partially clear, as well as the mechanism of actions that sustain these processes. This represents a clear challenge for future research projects that will also need to understand which role is exerted by viruses, parasites, and yeasts.
AB - Introduction: Helicobacter pylori (Hp) infection produces drastic changes in the gastric microenvironment, which, in turn, influence the gastric microbiota composition and might be correlated with large intestinal microbiota changes. This excellent perturbing actor could trigger important modifications in the homeostatic functions exerted by gut commensals leading to a new gastrointestinal balance. At the same time, the therapeutic strategies used to eradicate Hp can modulate this physiological symbiosis, but can be also conversely affected by its properties. Area covered: The purpose of this review is to explore the reciprocal interplay between Hp infection and gut microbiota and analyze how microbial changes can influence the management of Hp eradication therapies. Expert commentary: While many studies have described Hp-dependent gut microbiota alterations, their clinical implications are only partially clear, as well as the mechanism of actions that sustain these processes. This represents a clear challenge for future research projects that will also need to understand which role is exerted by viruses, parasites, and yeasts.
KW - Anti-Bacterial Agents
KW - Drug Therapy, Combination
KW - Dysbiosis
KW - Gastroenterology
KW - Gastrointestinal Microbiome
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Hepatology
KW - Host-Pathogen Interactions
KW - Humans
KW - Intestines
KW - Proton Pump Inhibitors
KW - Stomach
KW - Symbiosis
KW - Treatment Outcome
KW - dysbiosis
KW - eradication therapy
KW - gut microbiota
KW - proton pump inhibitor
KW - therapeutical strategies
KW - Anti-Bacterial Agents
KW - Drug Therapy, Combination
KW - Dysbiosis
KW - Gastroenterology
KW - Gastrointestinal Microbiome
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Hepatology
KW - Host-Pathogen Interactions
KW - Humans
KW - Intestines
KW - Proton Pump Inhibitors
KW - Stomach
KW - Symbiosis
KW - Treatment Outcome
KW - dysbiosis
KW - eradication therapy
KW - gut microbiota
KW - proton pump inhibitor
KW - therapeutical strategies
UR - http://hdl.handle.net/10807/129564
U2 - 10.1080/17474124.2018.1503946
DO - 10.1080/17474124.2018.1503946
M3 - Article
SN - 1747-4124
VL - 12
SP - 899
EP - 906
JO - EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
JF - EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
ER -