TY - JOUR
T1 - Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions
AU - Smolen, Josef S.
AU - Schoels, Monika M.
AU - Nishimoto, Norihiro
AU - Breedveld, Ferdinand C.
AU - Burmester, Gerd R.
AU - Dougados, Maxime
AU - Emery, Paul
AU - Ferraccioli, Gianfranco
AU - Gabay, Cem
AU - Gibofsky, Allan
AU - Gomez-Reino, Juan Jesus
AU - Jones, Graeme
AU - Kvien, Tore K.
AU - Murakami, Miho
AU - Betteridge, Neil
AU - Bingham Iii, Clifton O.
AU - Bykerk, Vivian
AU - Choy, Ernest H.
AU - Combe, Bernard
AU - Cutolo, Maurizio
AU - Graninger, Winfried
AU - Lanas, Angel
AU - Martin-Mola, Emilio
AU - Montecucco, Carlomaurizio
AU - Ostergaard, Mikkel
AU - Pavelka, Karel
AU - Rubbert-Roth, Andrea
AU - Sattar, Naveed
AU - Scholte-Voshaar, Marieke
AU - Tanaka, Yoshiya
AU - Trauner, Michael
AU - Valentini, Gabriele
AU - Winthrop, Kevin L.
AU - De Wit, Maarten
AU - Van Der Heijde, Désirée
PY - 2013
Y1 - 2013
N2 - Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ligand in various RA populations and other inflammatory diseases. This consensus document informs on interference with the IL-6 pathway based on evidence and expert opinion.
AB - Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ligand in various RA populations and other inflammatory diseases. This consensus document informs on interference with the IL-6 pathway based on evidence and expert opinion.
KW - interleukin-6
KW - rheumatoid arthritis
KW - interleukin-6
KW - rheumatoid arthritis
UR - http://hdl.handle.net/10807/41188
U2 - 10.1136/annrheumdis-2012-202469
DO - 10.1136/annrheumdis-2012-202469
M3 - Article
SN - 1468-2060
VL - 72
SP - 482
EP - 492
JO - EARD
JF - EARD
ER -