Comparison of beneficial actions of non-steroidal anti-inflammatory drugs to flavonoids

Franco Pandolfi, P. Conti, G. Varvara, G. Murmura, S. Tete, G. Sabatino, A. Saggini, M. Rosati, E. Toniato, A. Caraffa, P. Antinolfi, G. Potalivo, R. Galzio, T. C. Theoharides

Risultato della ricerca: Contributo in rivistaArticolo in rivista

20 Citazioni (Scopus)

Abstract

Inflammation is involved in increasing number of diseases necessitating the development of new, effective and safe treatments. Non steroidal anti-inflammatory drugs (NSAIDs) have been helpful in many instances, but they only inhibit cyclooxygenase (COX), but not the generation or actions of cytokines. Instead, some natural flavonoids have multiple anti-inflammatory effects, including COX inhibition, and a much safer profile. Increasing evidence indicates that inflammation plays a critical role in the pathogenesis of many diseases that also involve mast cells. Consequently, the need for new, effective and safe anti-inflammatory drugs is all the more urgent. Corticosteroids are quite potent, but have many adverse effects such as increased risk of infections, osteoporosis, glaucoma and depression. Biological agents such anti-TNF are useful in certain conditions, such as rheumatoid arthritis and psoriasis, but has been associated with increased risk of infection and leukemia.
Lingua originaleEnglish
pagine (da-a)1-7
Numero di pagine7
RivistaJOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Volume27
Stato di pubblicazionePubblicato - 2013

Keywords

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavonoids
  • Humans
  • Inflammation
  • Luteolin

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