Comparing the efficacy and safety of a first-line regimen with emtricitabine/tenofovir alafenamide fumarate plus either bictegravir or dolutegravir: Results from clinical practice

Arturo Ciccullo, Gianmaria Baldin, Vanni Borghi, Letizia Oreni, Filippo Lagi, Paolo Fusco, Andrea Giacomelli, Carlo Torti, Gaetana Sterrantino, Cristina Mussini, Spinello Antinori, Simona Di Giambenedetto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: First-line integrase strand transfer inhibitor-based regimens have become commonly used in clinical practice over the last decade. This study aimed to analyse and compare the efficacy and safety of bictegravir (BIC) and dolutegravir (DTG) when prescribed in association with emtricitabine/tenofovir alafenamide (FTC/TAF) as part of a first-line regimen for the treatment of human immunodeficiency-1 (HIV-1) infection.Methods: Treatment-naive people living with HIV (PLWHIV) starting a first-line regimen with either BIC/FTC/TAF (BIC group) or FTC/TAF + DTG (DTG group) were analysed. Snapshot analyses were performed after 24 and 48 weeks to evaluate virological efficacy. In addition, differences in the rate of treatment discontinuation (TD) between the two groups were evaluated using the Kaplan-Meier method and the log rank test.Results: Data from 327 PLWHIV were analysed: 140 in the DTG group and 187 in the BIC group. At 48 weeks, 90.0% of individuals in the DTG group and 86.7% of those in the BIC group achieved HIV -RNA < 50 copies/mL. In total, 88 and 38 cases of TD were observed in the DTG group and BIC group, respectively. The estimated probability of maintaining the study regimen at week 48 was 59.5% in the DTG group and 84.2% in the BIC group. Analysing changes in immunological parameters after 48 weeks, median improvements of + 169 cell/mm(3) ( P < 0.001) and + 233 cell/mm(3) ( P < 0.001) were observed in the DTG group and the BIC group, respectively.Conclusions: Both BIC and DTG, in combination with FTC/TAF, show promising efficacy and safety as first-line strategies in clinical practice, with favourable immunological recovery even in the short term.
Lingua originaleEnglish
pagine (da-a)1-3
Numero di pagine3
RivistaInternational Journal of Antimicrobial Agents
Volume63
DOI
Stato di pubblicazionePubblicato - 2024

Keywords

  • Bictegravir
  • Dolutegravir
  • First-line
  • HIV
  • Naïve

Fingerprint

Entra nei temi di ricerca di 'Comparing the efficacy and safety of a first-line regimen with emtricitabine/tenofovir alafenamide fumarate plus either bictegravir or dolutegravir: Results from clinical practice'. Insieme formano una fingerprint unica.

Cita questo