Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T Ottone; L Cicconi; Sk Hasan; S Lavorgna; M Divona; Maria Teresa Voso; E Montefusco; L Melillo; E Barragán; U Platzbecker; L Giannì; M Hubmann; M Pagoni; S Amadori; F. Lo Coco

doi:10.1016/j.leukres.2011.10.015

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T Ottone, L Cicconi, Sk Hasan, S Lavorgna, M Divona, Maria Teresa Voso, E Montefusco, L Melillo, E Barragán, U Platzbecker, L Giannì, M Hubmann, M Pagoni, S Amadori, F. Lo Coco

Risultato della ricerca: Contributo in rivista › Articolo › peer review

10 Citazioni (Scopus)

Abstract

Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

Lingua originale	Inglese
pagine (da-a)	474-478
Numero di pagine	5
Rivista	Leukemia Research
Volume	36
Numero di pubblicazione	4
DOI	https://doi.org/10.1016/j.leukres.2011.10.015
Stato di pubblicazione	Pubblicato - 2012
Pubblicato esternamente	Sì

All Science Journal Classification (ASJC) codes

Ematologia
Oncologia
Ricerca sul Cancro

Keywords

Acute
Adult
Aged
Antineoplastic Agents
Child
DNA (Cytosine-5-)-Methyltransferase
DNA Mutational Analysis
DNA-Binding Proteins
Female
Humans
Isocitrate Dehydrogenase
Leukemia
Male
Middle Aged
Promyelocytic
Proto-Oncogene Proteins
Radiotherapy
Young Adult
fms-Like Tyrosine Kinase 3

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10.1016/j.leukres.2011.10.015

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Ottone, T., Cicconi, L., Hasan, S., Lavorgna, S., Divona, M., Voso, M. T., Montefusco, E., Melillo, L., Barragán, E., Platzbecker, U., Giannì, L., Hubmann, M., Pagoni, M., Amadori, S., & Lo Coco, F. (2012). Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia. Leukemia Research, 36(4), 474-478. https://doi.org/10.1016/j.leukres.2011.10.015

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title = "Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia",

abstract = "Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.",

keywords = "Acute, Adult, Aged, Antineoplastic Agents, Child, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, DNA-Binding Proteins, Female, Humans, Isocitrate Dehydrogenase, Leukemia, Male, Middle Aged, Promyelocytic, Proto-Oncogene Proteins, Radiotherapy, Young Adult, fms-Like Tyrosine Kinase 3, Acute, Adult, Aged, Antineoplastic Agents, Child, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, DNA-Binding Proteins, Female, Humans, Isocitrate Dehydrogenase, Leukemia, Male, Middle Aged, Promyelocytic, Proto-Oncogene Proteins, Radiotherapy, Young Adult, fms-Like Tyrosine Kinase 3",

author = "T Ottone and L Cicconi and Sk Hasan and S Lavorgna and M Divona and Voso, {Maria Teresa} and E Montefusco and L Melillo and E Barrag{\'a}n and U Platzbecker and L Giann{\`i} and M Hubmann and M Pagoni and S Amadori and {Lo Coco}, F.",

year = "2012",

doi = "10.1016/j.leukres.2011.10.015",

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volume = "36",

pages = "474--478",

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Ottone, T, Cicconi, L, Hasan, S, Lavorgna, S, Divona, M, Voso, MT, Montefusco, E, Melillo, L, Barragán, E, Platzbecker, U, Giannì, L, Hubmann, M, Pagoni, M, Amadori, S & Lo Coco, F 2012, 'Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia', Leukemia Research, vol. 36, n. 4, pagg. 474-478. https://doi.org/10.1016/j.leukres.2011.10.015

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AU - Ottone, T

AU - Cicconi, L

AU - Hasan, Sk

AU - Lavorgna, S

AU - Divona, M

AU - Voso, Maria Teresa

AU - Montefusco, E

AU - Melillo, L

AU - Barragán, E

AU - Platzbecker, U

AU - Giannì, L

AU - Hubmann, M

AU - Pagoni, M

AU - Amadori, S

AU - Lo Coco, F.

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N2 - Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

AB - Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

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KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Child

KW - DNA (Cytosine-5-)-Methyltransferase

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KW - Humans

KW - Isocitrate Dehydrogenase

KW - Leukemia

KW - Male

KW - Middle Aged

KW - Promyelocytic

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KW - Young Adult

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KW - DNA (Cytosine-5-)-Methyltransferase

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

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KW - Humans

KW - Isocitrate Dehydrogenase

KW - Leukemia

KW - Male

KW - Middle Aged

KW - Promyelocytic

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KW - Radiotherapy

KW - Young Adult

KW - fms-Like Tyrosine Kinase 3

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U2 - 10.1016/j.leukres.2011.10.015

DO - 10.1016/j.leukres.2011.10.015

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SN - 0145-2126

VL - 36

SP - 474

EP - 478

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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