Abstract
Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
Lingua originale | English |
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pagine (da-a) | 474-478 |
Numero di pagine | 5 |
Rivista | Leukemia Research |
Volume | 36 |
DOI | |
Stato di pubblicazione | Pubblicato - 2012 |
Pubblicato esternamente | Sì |
Keywords
- Adult
- Aged
- Antineoplastic Agents
- Child
- DNA (Cytosine-5-)-Methyltransferase
- DNA Mutational Analysis
- DNA-Binding Proteins
- Female
- Humans
- Isocitrate Dehydrogenase
- Leukemia, Promyelocytic, Acute
- Male
- Middle Aged
- Proto-Oncogene Proteins
- Radiotherapy
- Young Adult
- fms-Like Tyrosine Kinase 3