Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T. Ottone; L. Cicconi; S. K. Hasan; S. Lavorgna; M. Divona; Maria Teresa Voso; E. Montefusco; L. Melillo; E. Barragán; U. Platzbecker; L. Giannì; M. Hubmann; M. Pagoni; S. Amadori; F. Lo-Coco

doi:10.1016/j.leukres.2011.10.015

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T. Ottone, L. Cicconi, S. K. Hasan, S. Lavorgna, M. Divona, Maria Teresa Voso, E. Montefusco, L. Melillo, E. Barragán, U. Platzbecker, L. Giannì, M. Hubmann, M. Pagoni, S. Amadori, F. Lo-Coco

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

10 Citazioni (Scopus)

Abstract

Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

Lingua originale	English
pagine (da-a)	474-478
Numero di pagine	5
Rivista	Leukemia Research
Volume	36
DOI	https://doi.org/10.1016/j.leukres.2011.10.015
Stato di pubblicazione	Pubblicato - 2012
Pubblicato esternamente	Sì

Keywords

Adult
Aged
Antineoplastic Agents
Child
DNA (Cytosine-5-)-Methyltransferase
DNA Mutational Analysis
DNA-Binding Proteins
Female
Humans
Isocitrate Dehydrogenase
Leukemia, Promyelocytic, Acute
Male
Middle Aged
Proto-Oncogene Proteins
Radiotherapy
Young Adult
fms-Like Tyrosine Kinase 3

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10.1016/j.leukres.2011.10.015

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Ottone, T., Cicconi, L., Hasan, S. K., Lavorgna, S., Divona, M., Voso, M. T., Montefusco, E., Melillo, L., Barragán, E., Platzbecker, U., Giannì, L., Hubmann, M., Pagoni, M., Amadori, S., & Lo-Coco, F. (2012). Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia. Leukemia Research, 36, 474-478. https://doi.org/10.1016/j.leukres.2011.10.015

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title = "Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia",

abstract = "Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.",

keywords = "Adult, Aged, Antineoplastic Agents, Child, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, DNA-Binding Proteins, Female, Humans, Isocitrate Dehydrogenase, Leukemia, Promyelocytic, Acute, Male, Middle Aged, Proto-Oncogene Proteins, Radiotherapy, Young Adult, fms-Like Tyrosine Kinase 3, Adult, Aged, Antineoplastic Agents, Child, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, DNA-Binding Proteins, Female, Humans, Isocitrate Dehydrogenase, Leukemia, Promyelocytic, Acute, Male, Middle Aged, Proto-Oncogene Proteins, Radiotherapy, Young Adult, fms-Like Tyrosine Kinase 3",

author = "T. Ottone and L. Cicconi and Hasan, {S. K.} and S. Lavorgna and M. Divona and Voso, {Maria Teresa} and E. Montefusco and L. Melillo and E. Barrag{\'a}n and U. Platzbecker and L. Giann{\`i} and M. Hubmann and M. Pagoni and S. Amadori and F. Lo-Coco",

year = "2012",

doi = "10.1016/j.leukres.2011.10.015",

language = "English",

volume = "36",

pages = "474--478",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Oxford,United Kingdom: Elsevier Science Limited -Oxford : Pergamon, 1977-",

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Ottone, T, Cicconi, L, Hasan, SK, Lavorgna, S, Divona, M, Voso, MT, Montefusco, E, Melillo, L, Barragán, E, Platzbecker, U, Giannì, L, Hubmann, M, Pagoni, M, Amadori, S & Lo-Coco, F 2012, 'Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia', Leukemia Research, vol. 36, pagg. 474-478. https://doi.org/10.1016/j.leukres.2011.10.015

TY - JOUR

T1 - Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

AU - Ottone, T.

AU - Cicconi, L.

AU - Hasan, S. K.

AU - Lavorgna, S.

AU - Divona, M.

AU - Voso, Maria Teresa

AU - Montefusco, E.

AU - Melillo, L.

AU - Barragán, E.

AU - Platzbecker, U.

AU - Giannì, L.

AU - Hubmann, M.

AU - Pagoni, M.

AU - Amadori, S.

AU - Lo-Coco, F.

PY - 2012

Y1 - 2012

N2 - Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

AB - Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Child

KW - DNA (Cytosine-5-)-Methyltransferase

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

KW - Female

KW - Humans

KW - Isocitrate Dehydrogenase

KW - Leukemia, Promyelocytic, Acute

KW - Male

KW - Middle Aged

KW - Proto-Oncogene Proteins

KW - Radiotherapy

KW - Young Adult

KW - fms-Like Tyrosine Kinase 3

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Child

KW - DNA (Cytosine-5-)-Methyltransferase

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

KW - Female

KW - Humans

KW - Isocitrate Dehydrogenase

KW - Leukemia, Promyelocytic, Acute

KW - Male

KW - Middle Aged

KW - Proto-Oncogene Proteins

KW - Radiotherapy

KW - Young Adult

KW - fms-Like Tyrosine Kinase 3

UR - http://hdl.handle.net/10807/2627

U2 - 10.1016/j.leukres.2011.10.015

DO - 10.1016/j.leukres.2011.10.015

M3 - Article

SN - 0145-2126

VL - 36

SP - 474

EP - 478

JO - Leukemia Research

JF - Leukemia Research

ER -

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Abstract

Keywords

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