Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Maria Teresa Voso; T Ottone; L Cicconi; Sk Hasan; S Lavorgna; M Divona; E Montefusco; L Melillo; E Barragán; U Platzbecker; L Giannì; M Hubmann; M Pagoni; S Amadori; F. Lo Coco

doi:10.1016/j.leukres.2011.10.015

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Maria Teresa Voso, T Ottone, L Cicconi, Sk Hasan, S Lavorgna, M Divona, E Montefusco, L Melillo, E Barragán, U Platzbecker, L Giannì, M Hubmann, M Pagoni, S Amadori, F. Lo Coco

Facoltà di Medicina e Chirurgia "A.Gemelli"

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

10 Citazioni (Scopus)

Abstract

Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

Lingua originale	English
pagine (da-a)	474-478
Numero di pagine	5
Rivista	Leukemia Research
Volume	36
DOI	https://doi.org/10.1016/j.leukres.2011.10.015
Stato di pubblicazione	Pubblicato - 2012

Keywords

Adult
Aged
Antineoplastic Agents
Child
DNA (Cytosine-5-)-Methyltransferase
DNA Mutational Analysis
DNA-Binding Proteins
Female
Humans
Isocitrate Dehydrogenase
Leukemia, Promyelocytic, Acute
Male
Middle Aged
Proto-Oncogene Proteins
Radiotherapy
Young Adult
fms-Like Tyrosine Kinase 3

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10.1016/j.leukres.2011.10.015

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Voso, M. T., Ottone, T., Cicconi, L., Hasan, S., Lavorgna, S., Divona, M., Montefusco, E., Melillo, L., Barragán, E., Platzbecker, U., Giannì, L., Hubmann, M., Pagoni, M., Amadori, S., & Lo Coco, F. (2012). Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia. Leukemia Research, 36, 474-478. https://doi.org/10.1016/j.leukres.2011.10.015

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title = "Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia",

abstract = "Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.",

keywords = "Adult, Aged, Antineoplastic Agents, Child, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, DNA-Binding Proteins, Female, Humans, Isocitrate Dehydrogenase, Leukemia, Promyelocytic, Acute, Male, Middle Aged, Proto-Oncogene Proteins, Radiotherapy, Young Adult, fms-Like Tyrosine Kinase 3, Adult, Aged, Antineoplastic Agents, Child, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, DNA-Binding Proteins, Female, Humans, Isocitrate Dehydrogenase, Leukemia, Promyelocytic, Acute, Male, Middle Aged, Proto-Oncogene Proteins, Radiotherapy, Young Adult, fms-Like Tyrosine Kinase 3",

author = "Voso, {Maria Teresa} and T Ottone and L Cicconi and Sk Hasan and S Lavorgna and M Divona and E Montefusco and L Melillo and E Barrag{\'a}n and U Platzbecker and L Giann{\`i} and M Hubmann and M Pagoni and S Amadori and {Lo Coco}, F.",

year = "2012",

doi = "10.1016/j.leukres.2011.10.015",

language = "English",

volume = "36",

pages = "474--478",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Oxford,United Kingdom: Elsevier Science Limited -Oxford : Pergamon, 1977-",

}

Voso, MT, Ottone, T, Cicconi, L, Hasan, S, Lavorgna, S, Divona, M, Montefusco, E, Melillo, L, Barragán, E, Platzbecker, U, Giannì, L, Hubmann, M, Pagoni, M, Amadori, S & Lo Coco, F 2012, 'Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia', Leukemia Research, vol. 36, pagg. 474-478. https://doi.org/10.1016/j.leukres.2011.10.015

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia. / Voso, Maria Teresa; Ottone, T; Cicconi, L; Hasan, Sk; Lavorgna, S; Divona, M; Montefusco, E; Melillo, L; Barragán, E; Platzbecker, U; Giannì, L; Hubmann, M; Pagoni, M; Amadori, S; Lo Coco, F.

In: Leukemia Research, Vol. 36, 2012, pag. 474-478.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

AU - Voso, Maria Teresa

AU - Ottone, T

AU - Cicconi, L

AU - Hasan, Sk

AU - Lavorgna, S

AU - Divona, M

AU - Montefusco, E

AU - Melillo, L

AU - Barragán, E

AU - Platzbecker, U

AU - Giannì, L

AU - Hubmann, M

AU - Pagoni, M

AU - Amadori, S

AU - Lo Coco, F.

PY - 2012

Y1 - 2012

N2 - Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

AB - Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Child

KW - DNA (Cytosine-5-)-Methyltransferase

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

KW - Female

KW - Humans

KW - Isocitrate Dehydrogenase

KW - Leukemia, Promyelocytic, Acute

KW - Male

KW - Middle Aged

KW - Proto-Oncogene Proteins

KW - Radiotherapy

KW - Young Adult

KW - fms-Like Tyrosine Kinase 3

KW - Adult

KW - Aged

KW - Antineoplastic Agents

KW - Child

KW - DNA (Cytosine-5-)-Methyltransferase

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

KW - Female

KW - Humans

KW - Isocitrate Dehydrogenase

KW - Leukemia, Promyelocytic, Acute

KW - Male

KW - Middle Aged

KW - Proto-Oncogene Proteins

KW - Radiotherapy

KW - Young Adult

KW - fms-Like Tyrosine Kinase 3

UR - http://hdl.handle.net/10807/2627

U2 - 10.1016/j.leukres.2011.10.015

DO - 10.1016/j.leukres.2011.10.015

M3 - Article

VL - 36

SP - 474

EP - 478

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

ER -

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Abstract

Keywords

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