Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T. Ottone, L. Cicconi, S. K. Hasan, S. Lavorgna, M. Divona, Maria Teresa Voso, E. Montefusco, L. Melillo, E. Barragán, U. Platzbecker, L. Giannì, M. Hubmann, M. Pagoni, S. Amadori, F. Lo-Coco

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)


Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
Lingua originaleEnglish
pagine (da-a)474-478
Numero di pagine5
RivistaLeukemia Research
Stato di pubblicazionePubblicato - 2012
Pubblicato esternamente


  • Adult
  • Aged
  • Antineoplastic Agents
  • Child
  • DNA (Cytosine-5-)-Methyltransferase
  • DNA Mutational Analysis
  • DNA-Binding Proteins
  • Female
  • Humans
  • Isocitrate Dehydrogenase
  • Leukemia, Promyelocytic, Acute
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins
  • Radiotherapy
  • Young Adult
  • fms-Like Tyrosine Kinase 3


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