Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

T Ottone, L Cicconi, Sk Hasan, S Lavorgna, M Divona, Maria Teresa Voso, E Montefusco, L Melillo, E Barragán, U Platzbecker, L Giannì, M Hubmann, M Pagoni, S Amadori, F. Lo Coco

Risultato della ricerca: Contributo in rivistaArticolopeer review

10 Citazioni (Scopus)

Abstract

Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
Lingua originaleInglese
pagine (da-a)474-478
Numero di pagine5
RivistaLeukemia Research
Volume36
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 2012
Pubblicato esternamente

All Science Journal Classification (ASJC) codes

  • Ematologia
  • Oncologia
  • Ricerca sul Cancro

Keywords

  • Acute
  • Adult
  • Aged
  • Antineoplastic Agents
  • Child
  • DNA (Cytosine-5-)-Methyltransferase
  • DNA Mutational Analysis
  • DNA-Binding Proteins
  • Female
  • Humans
  • Isocitrate Dehydrogenase
  • Leukemia
  • Male
  • Middle Aged
  • Promyelocytic
  • Proto-Oncogene Proteins
  • Radiotherapy
  • Young Adult
  • fms-Like Tyrosine Kinase 3

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