Comparative evaluation of two perfusion solutions for liver preservation and transplantation.

Alfonso Wolfango Avolio; Salvatore Agnes; Erida Nure; Giorgio Maria; Raffaella Barbarino; Gilda Pepe; Marco Castagneto

Comparative evaluation of two perfusion solutions for liver preservation and transplantation.

Alfonso Wolfango Avolio, Salvatore Agnes, Erida Nure, Giorgio Maria, Raffaella Barbarino, Gilda Pepe, Marco Castagneto

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

The University of Wisconsin solution (UW) and the Bretschneider solution (HTK) were used in 39 adult cadaveric donors: 22 perfused with UW (group 1) and 17 with HTK (group II). Donors were flushed through the aorta (UW, 5 to 6 L; HTK, 8 to 10 L) and through the portal vein (UW or HTK, 1 L). Grafts perfused with HTK showed lower levels of SGOT at postoperative day 7 than those transplanted with UW (38 +/- 19 vs 58 +/- 31, P < .05). No difference was observed in other functional and outcome parameters. No cases of primary dysfunction were observed. Six-month graft survival was 85.7% in HTK group and 80.9% in UW group (P = NS). Six unrelated deaths were observed. Five biliary complications were observed in five patients: three in the UW group and two in the HTK group. In conclusion, data fail to show major differences between the two solutions used.

Lingua originale	English
pagine (da-a)	1066-1067
Numero di pagine	2
Rivista	Transplantation Proceedings
Stato di pubblicazione	Pubblicato - 2006

Keywords

Donor
HTK
Liver transplantation
Organ Procurement
Perfusion solution
Wisconsin

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title = "Comparative evaluation of two perfusion solutions for liver preservation and transplantation.",

abstract = "The University of Wisconsin solution (UW) and the Bretschneider solution (HTK) were used in 39 adult cadaveric donors: 22 perfused with UW (group 1) and 17 with HTK (group II). Donors were flushed through the aorta (UW, 5 to 6 L; HTK, 8 to 10 L) and through the portal vein (UW or HTK, 1 L). Grafts perfused with HTK showed lower levels of SGOT at postoperative day 7 than those transplanted with UW (38 +/- 19 vs 58 +/- 31, P < .05). No difference was observed in other functional and outcome parameters. No cases of primary dysfunction were observed. Six-month graft survival was 85.7% in HTK group and 80.9% in UW group (P = NS). Six unrelated deaths were observed. Five biliary complications were observed in five patients: three in the UW group and two in the HTK group. In conclusion, data fail to show major differences between the two solutions used.",

keywords = "Donor, HTK, Liver transplantation, Organ Procurement, Perfusion solution, Wisconsin, Donor, HTK, Liver transplantation, Organ Procurement, Perfusion solution, Wisconsin",

author = "Avolio, {Alfonso Wolfango} and Salvatore Agnes and Erida Nure and Giorgio Maria and Raffaella Barbarino and Gilda Pepe and Marco Castagneto",

year = "2006",

language = "English",

pages = "1066--1067",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680",

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TY - JOUR

T1 - Comparative evaluation of two perfusion solutions for liver preservation and transplantation.

AU - Avolio, Alfonso Wolfango

AU - Agnes, Salvatore

AU - Nure, Erida

AU - Maria, Giorgio

AU - Barbarino, Raffaella

AU - Pepe, Gilda

AU - Castagneto, Marco

PY - 2006

Y1 - 2006

N2 - The University of Wisconsin solution (UW) and the Bretschneider solution (HTK) were used in 39 adult cadaveric donors: 22 perfused with UW (group 1) and 17 with HTK (group II). Donors were flushed through the aorta (UW, 5 to 6 L; HTK, 8 to 10 L) and through the portal vein (UW or HTK, 1 L). Grafts perfused with HTK showed lower levels of SGOT at postoperative day 7 than those transplanted with UW (38 +/- 19 vs 58 +/- 31, P < .05). No difference was observed in other functional and outcome parameters. No cases of primary dysfunction were observed. Six-month graft survival was 85.7% in HTK group and 80.9% in UW group (P = NS). Six unrelated deaths were observed. Five biliary complications were observed in five patients: three in the UW group and two in the HTK group. In conclusion, data fail to show major differences between the two solutions used.

AB - The University of Wisconsin solution (UW) and the Bretschneider solution (HTK) were used in 39 adult cadaveric donors: 22 perfused with UW (group 1) and 17 with HTK (group II). Donors were flushed through the aorta (UW, 5 to 6 L; HTK, 8 to 10 L) and through the portal vein (UW or HTK, 1 L). Grafts perfused with HTK showed lower levels of SGOT at postoperative day 7 than those transplanted with UW (38 +/- 19 vs 58 +/- 31, P < .05). No difference was observed in other functional and outcome parameters. No cases of primary dysfunction were observed. Six-month graft survival was 85.7% in HTK group and 80.9% in UW group (P = NS). Six unrelated deaths were observed. Five biliary complications were observed in five patients: three in the UW group and two in the HTK group. In conclusion, data fail to show major differences between the two solutions used.

KW - Donor

KW - HTK

KW - Liver transplantation

KW - Organ Procurement

KW - Perfusion solution

KW - Wisconsin

KW - Donor

KW - HTK

KW - Liver transplantation

KW - Organ Procurement

KW - Perfusion solution

KW - Wisconsin

UR - http://hdl.handle.net/10807/37123

UR - http://www.transplantation-proceedings.org

M3 - Article

SP - 1066

EP - 1067

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

ER -