Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Luca Laurenti, D Crowther Swanepoel, Mc Di Bernardo, K Jamroziak, L Karabon, I Frydecka, S Deaglio, G D'Arena, Dario Rossi, G Gaidano, B Olver, A Lloyd, P Broderick, Z Szemraj Rogucka, T Robak, D Catovsky, Rs Houlston

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.
Lingua originaleEnglish
pagine (da-a)229-233
Numero di pagine5
RivistaBritish Journal of Haematology
Volume154
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Case-Control Studies
  • Chromosomes, Human, Pair 15
  • Chromosomes, Human, Pair 18
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

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