Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Luca Laurenti; D Crowther Swanepoel; Mc Di Bernardo; K Jamroziak; L Karabon; I Frydecka; S Deaglio; G D'Arena; Dario Rossi; G Gaidano; B Olver; A Lloyd; P Broderick; Z Szemraj Rogucka; T Robak; D Catovsky; Rs Houlston

doi:10.1111/j.1365-2141.2011.08706.x

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Luca Laurenti, D Crowther Swanepoel, Mc Di Bernardo, K Jamroziak, L Karabon, I Frydecka, S Deaglio, G D'Arena, Dario Rossi, G Gaidano, B Olver, A Lloyd, P Broderick, Z Szemraj Rogucka, T Robak, D Catovsky, Rs Houlston

Risultato della ricerca: Contributo in rivista › Articolo in rivista

18 Citazioni (Scopus)

Abstract

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

Lingua originale	English
pagine (da-a)	229-233
Numero di pagine	5
Rivista	British Journal of Haematology
Volume	154
DOI	https://doi.org/10.1111/j.1365-2141.2011.08706.x
Stato di pubblicazione	Pubblicato - 2011

Keywords

Aged
Case-Control Studies
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 18
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Polymorphism, Single Nucleotide

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10.1111/j.1365-2141.2011.08706.x

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Laurenti, L., Crowther Swanepoel, D., Di Bernardo, M., Jamroziak, K., Karabon, L., Frydecka, I., Deaglio, S., D'Arena, G., Rossi, D., Gaidano, G., Olver, B., Lloyd, A., Broderick, P., Szemraj Rogucka, Z., Robak, T., Catovsky, D., & Houlston, R. (2011). Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. British Journal of Haematology, 154, 229-233. https://doi.org/10.1111/j.1365-2141.2011.08706.x

Laurenti, Luca ; Crowther Swanepoel, D ; Di Bernardo, Mc ; Jamroziak, K ; Karabon, L ; Frydecka, I ; Deaglio, S ; D'Arena, G ; Rossi, Dario ; Gaidano, G ; Olver, B ; Lloyd, A ; Broderick, P ; Szemraj Rogucka, Z ; Robak, T ; Catovsky, D ; Houlston, Rs. / Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. In: British Journal of Haematology. 2011 ; Vol. 154. pagg. 229-233.

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title = "Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk",

abstract = "A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.",

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author = "Luca Laurenti and {Crowther Swanepoel}, D and {Di Bernardo}, Mc and K Jamroziak and L Karabon and I Frydecka and S Deaglio and G D'Arena and Dario Rossi and G Gaidano and B Olver and A Lloyd and P Broderick and {Szemraj Rogucka}, Z and T Robak and D Catovsky and Rs Houlston",

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doi = "10.1111/j.1365-2141.2011.08706.x",

language = "English",

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pages = "229--233",

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publisher = "Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205",

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Laurenti, L, Crowther Swanepoel, D, Di Bernardo, M, Jamroziak, K, Karabon, L, Frydecka, I, Deaglio, S, D'Arena, G, Rossi, D, Gaidano, G, Olver, B, Lloyd, A, Broderick, P, Szemraj Rogucka, Z, Robak, T, Catovsky, D & Houlston, R 2011, 'Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk', British Journal of Haematology, vol. 154, pagg. 229-233. https://doi.org/10.1111/j.1365-2141.2011.08706.x

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. / Laurenti, Luca; Crowther Swanepoel, D; Di Bernardo, Mc; Jamroziak, K; Karabon, L; Frydecka, I; Deaglio, S; D'Arena, G; Rossi, Dario; Gaidano, G; Olver, B; Lloyd, A; Broderick, P; Szemraj Rogucka, Z; Robak, T; Catovsky, D; Houlston, Rs.

In: British Journal of Haematology, Vol. 154, 2011, pag. 229-233.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

AU - Laurenti, Luca

AU - Crowther Swanepoel, D

AU - Di Bernardo, Mc

AU - Jamroziak, K

AU - Karabon, L

AU - Frydecka, I

AU - Deaglio, S

AU - D'Arena, G

AU - Rossi, Dario

AU - Gaidano, G

AU - Olver, B

AU - Lloyd, A

AU - Broderick, P

AU - Szemraj Rogucka, Z

AU - Robak, T

AU - Catovsky, D

AU - Houlston, Rs

PY - 2011

Y1 - 2011

N2 - A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

AB - A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

KW - Aged

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 15

KW - Chromosomes, Human, Pair 18

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Aged

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 15

KW - Chromosomes, Human, Pair 18

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

UR - http://hdl.handle.net/10807/4957

U2 - 10.1111/j.1365-2141.2011.08706.x

DO - 10.1111/j.1365-2141.2011.08706.x

M3 - Article

VL - 154

SP - 229

EP - 233

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

ER -

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Abstract

Keywords

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