Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

D Crowther Swanepoel; Mc Di Bernardo; K Jamroziak; L Karabon; I Frydecka; S Deaglio; G D'Arena; Dario Rossi; G Gaidano; B Olver; A Lloyd; P Broderick; Luca Laurenti; Z Szemraj Rogucka; T Robak; D Catovsky; Rs Houlston

doi:10.1111/j.1365-2141.2011.08706.x

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

D Crowther Swanepoel, Mc Di Bernardo, K Jamroziak, L Karabon, I Frydecka, S Deaglio, G D'Arena, Dario Rossi, G Gaidano, B Olver, A Lloyd, P Broderick, Luca Laurenti, Z Szemraj Rogucka, T Robak, D Catovsky, Rs Houlston

Risultato della ricerca: Contributo in rivista › Articolo

18 Citazioni (Scopus)

Abstract

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

Lingua originale	Inglese
pagine (da-a)	229-233
Numero di pagine	5
Rivista	British Journal of Haematology
Volume	154
DOI	https://doi.org/10.1111/j.1365-2141.2011.08706.x
Stato di pubblicazione	Pubblicato - 2011

Keywords

Aged
Case-Control Studies
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 18
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Polymorphism, Single Nucleotide

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1111/j.1365-2141.2011.08706.x

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Crowther Swanepoel, D., Di Bernardo, M., Jamroziak, K., Karabon, L., Frydecka, I., Deaglio, S., D'Arena, G., Rossi, D., Gaidano, G., Olver, B., Lloyd, A., Broderick, P., Laurenti, L., Szemraj Rogucka, Z., Robak, T., Catovsky, D., & Houlston, R. (2011). Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. British Journal of Haematology, 154, 229-233. https://doi.org/10.1111/j.1365-2141.2011.08706.x

@article{919528f863b14462b7efde4187028c10,

title = "Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk",

abstract = "A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.",

keywords = "Aged, Case-Control Studies, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 18, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Polymorphism, Single Nucleotide, Aged, Case-Control Studies, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 18, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Polymorphism, Single Nucleotide",

author = "{Crowther Swanepoel}, D and {Di Bernardo}, Mc and K Jamroziak and L Karabon and I Frydecka and S Deaglio and G D'Arena and Dario Rossi and G Gaidano and B Olver and A Lloyd and P Broderick and Luca Laurenti and {Szemraj Rogucka}, Z and T Robak and D Catovsky and Rs Houlston",

year = "2011",

doi = "10.1111/j.1365-2141.2011.08706.x",

language = "English",

volume = "154",

pages = "229--233",

journal = "British Journal of Haematology",

issn = "1365-2141",

publisher = "John Wiley and Sons Inc.",

}

Crowther Swanepoel, D, Di Bernardo, M, Jamroziak, K, Karabon, L, Frydecka, I, Deaglio, S, D'Arena, G, Rossi, D, Gaidano, G, Olver, B, Lloyd, A, Broderick, P, Laurenti, L, Szemraj Rogucka, Z, Robak, T, Catovsky, D & Houlston, R 2011, 'Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk', British Journal of Haematology, vol. 154, pagg. 229-233. https://doi.org/10.1111/j.1365-2141.2011.08706.x

TY - JOUR

T1 - Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

AU - Crowther Swanepoel, D

AU - Di Bernardo, Mc

AU - Jamroziak, K

AU - Karabon, L

AU - Frydecka, I

AU - Deaglio, S

AU - D'Arena, G

AU - Rossi, Dario

AU - Gaidano, G

AU - Olver, B

AU - Lloyd, A

AU - Broderick, P

AU - Laurenti, Luca

AU - Szemraj Rogucka, Z

AU - Robak, T

AU - Catovsky, D

AU - Houlston, Rs

PY - 2011

Y1 - 2011

N2 - A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

AB - A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P(combined) = 1·10 × 10(-7) and 1·30 × 10(-5) respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

KW - Aged

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 15

KW - Chromosomes, Human, Pair 18

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Aged

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 15

KW - Chromosomes, Human, Pair 18

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

UR - http://hdl.handle.net/10807/4957

U2 - 10.1111/j.1365-2141.2011.08706.x

DO - 10.1111/j.1365-2141.2011.08706.x

M3 - Article

SN - 1365-2141

VL - 154

SP - 229

EP - 233

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Abstract

Keywords

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo