Common genetic variation and the control of HIV-1 in humans.

Andrea De Luca; J Fellay; D Ge; Kv Shianna; S Colombo; B Ledergerber; Et Cirulli; Tj Urban; K Zhang; Ge Gumbs; Jp Smith; A Castagna; A Cozzi Lepri; P Easterbrook; Hf Gunthard; S Mallal; C Mussini; J Dalmau; J Martinez Picado; Study Group Chavi

Common genetic variation and the control of HIV-1 in humans.

Andrea De Luca, J Fellay, D Ge, Kv Shianna, S Colombo, B Ledergerber, Et Cirulli, Tj Urban, K Zhang, Ge Gumbs, Jp Smith, A Castagna, A Cozzi Lepri, P Easterbrook, Hf Gunthard, S Mallal, C Mussini, J Dalmau, J Martinez Picado, Study Group Chavi

Facoltà di Medicina e Chirurgia "A.Gemelli"

Risultato della ricerca: Contributo in rivista › Articolo in rivista

304 Citazioni (Scopus)

Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Lingua originale	English
pagine (da-a)	e1000791-e1000791
Numero di pagine	1
Rivista	PLoS Genetics
Volume	5
Stato di pubblicazione	Pubblicato - 2009

Keywords

HIV

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De Luca, A., Fellay, J., Ge, D., Shianna, K., Colombo, S., Ledergerber, B., Cirulli, E., Urban, T., Zhang, K., Gumbs, G., Smith, J., Castagna, A., Cozzi Lepri, A., Easterbrook, P., Gunthard, H., Mallal, S., Mussini, C., Dalmau, J., Martinez Picado, J., & Chavi, S. G. (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genetics, 5, e1000791-e1000791.

De Luca, Andrea ; Fellay, J ; Ge, D ; Shianna, Kv ; Colombo, S ; Ledergerber, B ; Cirulli, Et ; Urban, Tj ; Zhang, K ; Gumbs, Ge ; Smith, Jp ; Castagna, A ; Cozzi Lepri, A ; Easterbrook, P ; Gunthard, Hf ; Mallal, S ; Mussini, C ; Dalmau, J ; Martinez Picado, J ; Chavi, Study Group. / Common genetic variation and the control of HIV-1 in humans. In: PLoS Genetics. 2009 ; Vol. 5. pagg. e1000791-e1000791.

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abstract = "To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.",

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Common genetic variation and the control of HIV-1 in humans. / De Luca, Andrea; Fellay, J; Ge, D; Shianna, Kv; Colombo, S; Ledergerber, B; Cirulli, Et; Urban, Tj; Zhang, K; Gumbs, Ge; Smith, Jp; Castagna, A; Cozzi Lepri, A; Easterbrook, P; Gunthard, Hf; Mallal, S; Mussini, C; Dalmau, J; Martinez Picado, J; Chavi, Study Group.

In: PLoS Genetics, Vol. 5, 2009, pag. e1000791-e1000791.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Common genetic variation and the control of HIV-1 in humans.

AU - De Luca, Andrea

AU - Fellay, J

AU - Ge, D

AU - Shianna, Kv

AU - Colombo, S

AU - Ledergerber, B

AU - Cirulli, Et

AU - Urban, Tj

AU - Zhang, K

AU - Gumbs, Ge

AU - Smith, Jp

AU - Castagna, A

AU - Cozzi Lepri, A

AU - Easterbrook, P

AU - Gunthard, Hf

AU - Mallal, S

AU - Mussini, C

AU - Dalmau, J

AU - Martinez Picado, J

AU - Chavi, Study Group

PY - 2009

Y1 - 2009

N2 - To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

AB - To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

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