Common genetic variation and the control of HIV-1 in humans.

Andrea De Luca, J Fellay, D Ge, Kv Shianna, S Colombo, B Ledergerber, Et Cirulli, Tj Urban, K Zhang, Ge Gumbs, Jp Smith, A Castagna, A Cozzi Lepri, P Easterbrook, Hf Gunthard, S Mallal, C Mussini, J Dalmau, J Martinez Picado, Study Group Chavi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

304 Citazioni (Scopus)

Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Lingua originaleEnglish
pagine (da-a)e1000791-e1000791
Numero di pagine1
RivistaPLoS Genetics
Volume5
Stato di pubblicazionePubblicato - 2009

Keywords

  • HIV

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