Combination of biological and morphological parameters for the selection of patients with hepatocellular carcinoma waiting for liver transplantation.

Alfonso Wolfango Avolio, Salvatore Agnes, Quirino Lai, Tommaso Maria Manzia, Roberto Sorge, Giuseppe Tisone, Pasquale Berloco, Massimo Rossi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

42 Citazioni (Scopus)

Abstract

Abstract: Background: In the last several years, there has been no agreement on how to possibly expand the Milan criteria (MC) in the selection of patients with hepatocellular carcinoma (HCC) for listing for liver transplant (LT). The aim of the study is to evaluate morphological and biological tumor parameters to identify new expanded criteria for the selection of patients with HCC as candidates for LT. Methods: We retrospectively analyzed 158 consecutive patients with HCC who underwent LT. Results: Twelve (7.6%) recurrences were observed. At multivariate analysis, alpha-fetoprotein (AFP) >400 ng/mL (odds ratio [OR] 8.4, p < 0.01) and total tumor diameter (TTD) >8 cm (OR 7.4, p = 0.01) were the strongest predictors for recurrence. AFP-TTD criteria resulted in a low five-yr recurrence rate (4.9%) and an increased number of LT compared with the MC (22.2% increase). The five-yr disease-free survival rate was 74.4% in AFP-TTD criteria in patients, with a higher effectiveness in stratifying the cohort with respect to the MC. Conclusions: Both AFP and TTD are good independent predictors of HCC recurrence. Their combination appears to obtain a better selection of can- didates for LT without worsening patient survival and recurrence rates. This approach allows for an increase in the number of potentially transplantable patients.
Lingua originaleEnglish
pagine (da-a)125-131
Numero di pagine7
RivistaClinical Transplantation
Volume26
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • ALPHA FETOPROTEIN
  • HEPATOCELLULAR CARCINOMA
  • LIVER TRANSPLANTATION
  • MILAN CRITERIA
  • WAITING LIST

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