Colorectal cancer stem cells: from the crypt to the clinic

Ruggero De Maria Marchiano, Ann Zeuner, Matilde Todaro, Giorgio Stassi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

208 Citazioni (Scopus)

Abstract

Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal cancer and how understanding CSC plasticity can improve the development of clinical strategies.
Lingua originaleEnglish
pagine (da-a)692-705
Numero di pagine14
RivistaCell Stem Cell
Volume15
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Animals
  • Colonic Neoplasms
  • Colorectal Neoplasms
  • Disease Models, Animal
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Intestines
  • Neoplastic Stem Cells
  • Pluripotent Stem Cells
  • Tumor Escape

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