Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

R. Battini; Daniela Pia Rosaria Chieffo; S. Bulgheroni; G. Piccini; C. Pecini; S. Lucibello; S. Lenzi; F. Moriconi; Marika Pane; G. Astrea; G. Baranello; P. Alfieri; Stefano Vicari; D. Riva; G. Cioni; Eugenio Maria Mercuri

doi:10.1016/j.nmd.2017.11.018

Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

R. Battini, Daniela Pia Rosaria Chieffo, S. Bulgheroni, G. Piccini, C. Pecini, S. Lucibello, S. Lenzi, F. Moriconi, Marika Pane, G. Astrea, G. Baranello, P. Alfieri, Stefano Vicari, D. Riva, G. Cioni, Eugenio Maria Mercuri^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

The aim of our prospective observational study was to assess profiles of cognitive function and a possible impairment of executive functions in a cohort of boys with Duchenne muscular dystrophy without intellectual and behavior disability. Forty Duchenne boys (range of age: 6 years to 11 years and 6 months) were assessed by Wechsler Intelligence scale and battery of tests including tasks assessing working memory and executive functions (inhibition and switching, problem solving and planning). In our cohort some aspects of cognitive function were often impaired. These included multitasking, problem solving, inhibition and working memory necessary to plan and direct goal oriented behavior. Our results support the suggestion that aspects of cognitive function could be impaired even in boys without intellectual disability and support the hypothesis that executive functions may play an important role in specific aspects of cognitive impairment in Duchenne muscular dystrophy.

Lingua originale	Inglese
pagine (da-a)	122-128
Numero di pagine	7
Rivista	Neuromuscular Disorders
Volume	28
Numero di pubblicazione	2
DOI	https://doi.org/10.1016/j.nmd.2017.11.018
Stato di pubblicazione	Pubblicato - 2018

All Science Journal Classification (ASJC) codes

Pediatria, Perinatologia e Salute del Bambino
Neurologia
Neurologia (clinica)
Genetica (clinica)

Keywords

Cerebellum
DMD
Executive functions
Neuropsychological profile
Working memory

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10.1016/j.nmd.2017.11.018

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Battini, R., Chieffo, D. P. R., Bulgheroni, S., Piccini, G., Pecini, C., Lucibello, S., Lenzi, S., Moriconi, F., Pane, M., Astrea, G., Baranello, G., Alfieri, P., Vicari, S., Riva, D., Cioni, G., & Mercuri, E. M. (2018). Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions. Neuromuscular Disorders, 28(2), 122-128. https://doi.org/10.1016/j.nmd.2017.11.018

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title = "Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions",

abstract = "The aim of our prospective observational study was to assess profiles of cognitive function and a possible impairment of executive functions in a cohort of boys with Duchenne muscular dystrophy without intellectual and behavior disability. Forty Duchenne boys (range of age: 6 years to 11 years and 6 months) were assessed by Wechsler Intelligence scale and battery of tests including tasks assessing working memory and executive functions (inhibition and switching, problem solving and planning). In our cohort some aspects of cognitive function were often impaired. These included multitasking, problem solving, inhibition and working memory necessary to plan and direct goal oriented behavior. Our results support the suggestion that aspects of cognitive function could be impaired even in boys without intellectual disability and support the hypothesis that executive functions may play an important role in specific aspects of cognitive impairment in Duchenne muscular dystrophy.",

keywords = "Cerebellum, DMD, Executive functions, Neuropsychological profile, Working memory, Cerebellum, DMD, Executive functions, Neuropsychological profile, Working memory",

author = "R. Battini and Chieffo, {Daniela Pia Rosaria} and S. Bulgheroni and G. Piccini and C. Pecini and S. Lucibello and S. Lenzi and F. Moriconi and Marika Pane and G. Astrea and G. Baranello and P. Alfieri and Stefano Vicari and D. Riva and G. Cioni and Mercuri, {Eugenio Maria}",

year = "2018",

doi = "10.1016/j.nmd.2017.11.018",

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Battini, R, Chieffo, DPR, Bulgheroni, S, Piccini, G, Pecini, C, Lucibello, S, Lenzi, S, Moriconi, F, Pane, M, Astrea, G, Baranello, G, Alfieri, P, Vicari, S, Riva, D, Cioni, G & Mercuri, EM 2018, 'Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions', Neuromuscular Disorders, vol. 28, n. 2, pagg. 122-128. https://doi.org/10.1016/j.nmd.2017.11.018

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AU - Battini, R.

AU - Chieffo, Daniela Pia Rosaria

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AU - Piccini, G.

AU - Pecini, C.

AU - Lucibello, S.

AU - Lenzi, S.

AU - Moriconi, F.

AU - Pane, Marika

AU - Astrea, G.

AU - Baranello, G.

AU - Alfieri, P.

AU - Vicari, Stefano

AU - Riva, D.

AU - Cioni, G.

AU - Mercuri, Eugenio Maria

PY - 2018

Y1 - 2018

N2 - The aim of our prospective observational study was to assess profiles of cognitive function and a possible impairment of executive functions in a cohort of boys with Duchenne muscular dystrophy without intellectual and behavior disability. Forty Duchenne boys (range of age: 6 years to 11 years and 6 months) were assessed by Wechsler Intelligence scale and battery of tests including tasks assessing working memory and executive functions (inhibition and switching, problem solving and planning). In our cohort some aspects of cognitive function were often impaired. These included multitasking, problem solving, inhibition and working memory necessary to plan and direct goal oriented behavior. Our results support the suggestion that aspects of cognitive function could be impaired even in boys without intellectual disability and support the hypothesis that executive functions may play an important role in specific aspects of cognitive impairment in Duchenne muscular dystrophy.

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KW - Executive functions

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KW - Working memory

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KW - Working memory

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Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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