Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions

Maria A Rocca; Ermelinda De Meo; Maria P Amato; Massimiliano Copetti; Lucia Moiola; Angelo Ghezzi; Pierangelo Veggiotti; Ruggero Capra; Agnese Fiorino; Lorena Pippolo; Maria Carmela Pera; Andrea Falini; Giancarlo Comi; Massimo Filippi

doi:10.1177/1352458514557303

Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions

Maria A Rocca, Ermelinda De Meo, Maria P Amato, Massimiliano Copetti, Lucia Moiola, Angelo Ghezzi, Pierangelo Veggiotti, Ruggero Capra, Agnese Fiorino, Lorena Pippolo, Maria Carmela Pera, Andrea Falini, Giancarlo Comi, Massimo Filippi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.

Lingua originale	English
pagine (da-a)	956-959
Numero di pagine	4
Rivista	Multiple Sclerosis
Volume	21
DOI	https://doi.org/10.1177/1352458514557303
Stato di pubblicazione	Pubblicato - 2015

Keywords

Adolescent
Brain
Cognition Disorders
Female
Humans
Image Interpretation, Computer-Assisted
MRI
Magnetic Resonance Imaging
Male
Multiple Sclerosis, Relapsing-Remitting
Neuropsychological Tests
Paediatric multiple sclerosis
cortical lesions
double inversion recovery
grey matter

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10.1177/1352458514557303

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title = "Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions",

abstract = "We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.",

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author = "Rocca, {Maria A} and {De Meo}, Ermelinda and Amato, {Maria P} and Massimiliano Copetti and Lucia Moiola and Angelo Ghezzi and Pierangelo Veggiotti and Ruggero Capra and Agnese Fiorino and Lorena Pippolo and Pera, {Maria Carmela} and Andrea Falini and Giancarlo Comi and Massimo Filippi",

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doi = "10.1177/1352458514557303",

language = "English",

volume = "21",

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journal = "Multiple Sclerosis Journal",

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T1 - Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions

AU - Rocca, Maria A

AU - De Meo, Ermelinda

AU - Amato, Maria P

AU - Copetti, Massimiliano

AU - Moiola, Lucia

AU - Ghezzi, Angelo

AU - Veggiotti, Pierangelo

AU - Capra, Ruggero

AU - Fiorino, Agnese

AU - Pippolo, Lorena

AU - Pera, Maria Carmela

AU - Falini, Andrea

AU - Comi, Giancarlo

AU - Filippi, Massimo

PY - 2015

Y1 - 2015

N2 - We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.

AB - We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.

KW - Adolescent

KW - Brain

KW - Cognition Disorders

KW - Female

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - MRI

KW - Magnetic Resonance Imaging

KW - Male

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Neuropsychological Tests

KW - Paediatric multiple sclerosis

KW - cortical lesions

KW - double inversion recovery

KW - grey matter

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KW - Brain

KW - Cognition Disorders

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KW - Image Interpretation, Computer-Assisted

KW - MRI

KW - Magnetic Resonance Imaging

KW - Male

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Neuropsychological Tests

KW - Paediatric multiple sclerosis

KW - cortical lesions

KW - double inversion recovery

KW - grey matter

UR - http://hdl.handle.net/10807/213591

U2 - 10.1177/1352458514557303

DO - 10.1177/1352458514557303

M3 - Article

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SP - 956

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JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

ER -

Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions

Abstract

Keywords

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