Cognitive Impairment in chronic obstructive pulmonary disease: a neuropsychological and spect study

Camillo Marra, Alessandro Giordano, Maria Lucia Calcagni, Leonello Fuso, Raffaele Antonelli Incalzi, Antonella Cappa, Gabriella Pagliari, Salvatore Basso

Risultato della ricerca: Contributo in rivistaArticolo in rivista

124 Citazioni (Scopus)

Abstract

Some analogy exists between cognitive impairment in hypoxemic patients with chronic obstructive pulmonary disease (COPD) and Alzheimer's disease (AD). We purposed to verify whether the analogy extends to the cerebral perfusion pattern. Ten normal subjects, 15 COPD patients with and 18 without hypoxemia, and 15 patients with mild AD matched for age and educational level underwent brain perfusion single photon emission computed tomography (SPECT) and neuropsychological assessment. Normal subjects and non hypoxemic COPD patients had comparable perfusion patterns. The average perfusion decreased from non hypoxemic to hypoxemic COPD and, then, to AD patients. Hypoperfusion of associative areas was the hallmark of AD, whereas the average perfusion of anterior cortical and subcortical regions did not distinguish AD and hypoxemic COPD patients. Both COPD groups scored higher than AD patients (p
Lingua originaleEnglish
pagine (da-a)325-332
Numero di pagine8
RivistaJournal of Neurology
Stato di pubblicazionePubblicato - 2003

Keywords

  • cognitive impairment
  • obstructive pulmonary disease
  • spet

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