TY - JOUR
T1 - Cognitive Impairment in chronic obstructive pulmonary disease: a neuropsychological and spect study
AU - Antonelli Incalzi, Raffaele
AU - Marra, Camillo
AU - Giordano, Alessandro
AU - Calcagni, Maria Lucia
AU - Cappa, Antonella
AU - Basso, Salvatore
AU - Pagliari, Gabriella
AU - Fuso, Leonello
PY - 2003
Y1 - 2003
N2 - Some analogy exists between cognitive impairment in hypoxemic patients with chronic obstructive pulmonary disease (COPD) and Alzheimer's disease (AD). We purposed to verify whether the analogy extends to the cerebral perfusion pattern. Ten normal subjects, 15 COPD patients with and 18 without hypoxemia, and 15 patients with mild AD matched for age and educational level underwent brain perfusion single photon emission computed tomography (SPECT) and neuropsychological assessment. Normal subjects and non hypoxemic COPD patients had comparable perfusion patterns. The average perfusion decreased from non hypoxemic to hypoxemic COPD and, then, to AD patients. Hypoperfusion of associative areas was the hallmark of AD, whereas the average perfusion of anterior cortical and subcortical regions did not distinguish AD and hypoxemic COPD patients. Both COPD groups scored higher than AD patients (p
AB - Some analogy exists between cognitive impairment in hypoxemic patients with chronic obstructive pulmonary disease (COPD) and Alzheimer's disease (AD). We purposed to verify whether the analogy extends to the cerebral perfusion pattern. Ten normal subjects, 15 COPD patients with and 18 without hypoxemia, and 15 patients with mild AD matched for age and educational level underwent brain perfusion single photon emission computed tomography (SPECT) and neuropsychological assessment. Normal subjects and non hypoxemic COPD patients had comparable perfusion patterns. The average perfusion decreased from non hypoxemic to hypoxemic COPD and, then, to AD patients. Hypoperfusion of associative areas was the hallmark of AD, whereas the average perfusion of anterior cortical and subcortical regions did not distinguish AD and hypoxemic COPD patients. Both COPD groups scored higher than AD patients (p
KW - cognitive impairment
KW - obstructive pulmonary disease
KW - spet
KW - cognitive impairment
KW - obstructive pulmonary disease
KW - spet
UR - http://hdl.handle.net/10807/10955
M3 - Article
SN - 0340-5354
SP - 325
EP - 332
JO - Journal of Neurology
JF - Journal of Neurology
ER -