Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Georgia Martimianaki, Paola Bertuccio, Gianfranco Alicandro, Claudio Pelucchi, Francesca Bravi, Greta Carioli, Rossella Bonzi, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Ken Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Nuno Lunet, Nuno Miguel De Sousa Lunet, Samantha Morais, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki HamadaLizbeth López-Carrillo, Raúl Ulises Hernández-Ramírez, David Zaridze, Dmitry Maximovitch, Nuria Aragonés, Vicente Martin, Mary H. Ward, Jesus Vioque, Manoli Garcia De La Hera, Zuo-Feng Zhang, Robert C. Kurtz, Pagona Lagiou, Areti Lagiou, Antonia Trichopoulou, Anna Karakatsani, Reza Malekzadeh, M. Constanza Camargo, Maria Paula Curado, Stefania Boccia, Paolo Boffetta, Eva Negri, Carlo La Vecchia

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Objective: This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods: A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. Results: Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. Conclusions: These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaEuropean Journal of Cancer Prevention
VolumePublish Ahead of Print
Stato di pubblicazionePubblicato - 2021


  • coffee consumption
  • gastric cancer


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