Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study.

Antonio Mancini, Giancarlo Balercia, Fabrizio Mosca, Francesco Mantero, Marco Boscaro, Giuseppe Ricciardo La Monica, Gianpaolo Littarru

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

OBJECTIVE: To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia. DESIGN: Open, uncontrolled pilot study. PATIENT(S): Infertile men with idiopathic asthenozoospermia. INTERVENTION(S): CoQ(10) was administered orally; semen samples were collected at baseline and after 6 months of therapy. MAIN OUTCOME MEASURE (S): Semen kinetic parameters, including computer-assisted sperm data and CoQ(10) and phosphatidylcholine levels. RESULT(S): CoQ(10) levels increased significantly in seminal plasma and in sperm cells after treatment. Phosphatidylcholine levels also increased. A significant increase was also found in sperm cell motility as confirmed by computer-assisted analysis. A positive dependence (using the Cramer's index of association) was evident among the relative variations, baseline and after treatment, of seminal plasma or intracellular CoQ(10) content and computer-determined kinetic parameters. CONCLUSION(S): The exogenous administration of CoQ(10) may play a positive role in the treatment of asthenozoospermia. This is probably the result of its role in mitochondrial bioenergetics and its antioxidant properties.
Lingua originaleEnglish
pagine (da-a)93-98
Numero di pagine6
RivistaFertility and Sterility
Stato di pubblicazionePubblicato - 2004

Keywords

  • ASTHENOZOOSPERMIA
  • COENZYME Q10
  • MALE INFERTILITY

Fingerprint Entra nei temi di ricerca di 'Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study.'. Insieme formano una fingerprint unica.

Cita questo