TY - JOUR
T1 - Coeliac disease under a microscope: Histological diagnostic features and confounding factors
AU - Gibiino, Giulia
AU - Lopetuso, Loris Riccardo
AU - Ricci, Riccardo
AU - Gasbarrini, Antonio
AU - Cammarota, Giovanni
PY - 2019
Y1 - 2019
N2 - Coeliac disease (CD) and gluten-related disorders represent an important cornerstone of the daily practice of gastroenterologists, endoscopists and dedicated histopathologists. Despite the knowledge of clinical, serological and histological typical lesions, there are some conditions to consider for differential diagnosis. From the first description of histology of CD, several studies were conducted to define similar findings suggestive for microscopic enteritis. Considering the establishment of early precursor lesions, the imbalance of gut microbiota is another point still requiring a detailed definition. This review assesses the importance of a right overview in case of suspected gluten-related disorders and the several conditions mimicking a similar histology.
AB - Coeliac disease (CD) and gluten-related disorders represent an important cornerstone of the daily practice of gastroenterologists, endoscopists and dedicated histopathologists. Despite the knowledge of clinical, serological and histological typical lesions, there are some conditions to consider for differential diagnosis. From the first description of histology of CD, several studies were conducted to define similar findings suggestive for microscopic enteritis. Considering the establishment of early precursor lesions, the imbalance of gut microbiota is another point still requiring a detailed definition. This review assesses the importance of a right overview in case of suspected gluten-related disorders and the several conditions mimicking a similar histology.
KW - Computer Science Applications1707 Computer Vision and Pattern Recognition
KW - Gluten
KW - Gut microbiota
KW - Health Informatics
KW - Intraepithelial lymphocyte (IEL)
KW - Microscopic enteritis
KW - Non-coeliac gluten-sensitivity
KW - Computer Science Applications1707 Computer Vision and Pattern Recognition
KW - Gluten
KW - Gut microbiota
KW - Health Informatics
KW - Intraepithelial lymphocyte (IEL)
KW - Microscopic enteritis
KW - Non-coeliac gluten-sensitivity
UR - http://hdl.handle.net/10807/129166
UR - http://www.elsevier.com/locate/compbiomed
U2 - 10.1016/j.compbiomed.2018.10.020
DO - 10.1016/j.compbiomed.2018.10.020
M3 - Article
SN - 0010-4825
VL - 104
SP - 335
EP - 338
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
ER -