Clinical Validation of Three-Dimensional Cardiac Magnetic Source Imaging Accuracy with Simultaneous Magnetocardiographic Mapping, Monophasic Action Potential Recordings and Amagnetic Cardiac Pacing

Riccardo Fenici, Peter Fenici, Donatella Brisinda, K Pesola, J Nenonen, M Mäkijärvi, A Giorgi, T Jokiniemi, P Korhonen, K Lauerma, J Lötjönen, Mp Ruggieri, M Valkonen, L Toivonen, T. Katila

Risultato della ricerca: Contributo in libroContributo a convegno

Abstract

This study validates, in patients., the accuracy of magnetocardiographic mapping (MCG) for three-dimensional (3D) localization of cardiac sources. A specially designed amagnetic catheter (AC), which tip generates current dipoles of different geometry and records monophasic action potential (MAP), was inserted in 10 patients, after routine EPS. Four MAPs were simultaneously recorded with the AC, to monitor the stability of endocardial contact before, during and after the MCG. The position of AC’tip was also imaged by biplane fluoroscopy (XR), together with lead markers. MCG studies were performed in the BioMag magnetically shielded room at. Current dipoles (5mm; 10mA) were activated at the AC’tip. For the MCG localizations of the AC’tip, the equivalent current dipole (ECD) model in patient-specific boundary element torso was used. The accuracy of the MCG localizations was evaluated by: 1) anatomical location of ECD in MRI, 2) mismatch with XR, 3) coherence between the localizations of AC’dipole and evoked myocardial response after 3 ms. The AC was in stable endocardial contact and was correctly localized in the right ventricle of all patients MRI. The mean 3D distance between XR and MCG localizations was 5±3 mm. The mean difference between the MCG localizations at the peak of the stimulus and 3 ms later was 41 mm. The 95% confidence interval of beat-to-beat localizations of AC’tip was 4±3 mm. With a sufficient signal-to-noise ratio, 3D dipole localizations of both stimulus spikes and evoked responses were accurate and reproducible. Thus MCG localizes cardiac sources with accuracy good enough for clinical applications.
Lingua originaleEnglish
Titolo della pubblicazione ospiteRecent advaces in Biomagnetism. Tohoku University Press, 1999
Pagine1026-1029
Numero di pagine4
Stato di pubblicazionePubblicato - 1999
Evento11th International Conference on Biomagnetism - Sendai
Durata: 28 ago 19982 set 1998

Convegno

Convegno11th International Conference on Biomagnetism
CittàSendai
Periodo28/8/982/9/98

Keywords

  • Magnetocardiography
  • Monophasic action potential

Fingerprint

Entra nei temi di ricerca di 'Clinical Validation of Three-Dimensional Cardiac Magnetic Source Imaging Accuracy with Simultaneous Magnetocardiographic Mapping, Monophasic Action Potential Recordings and Amagnetic Cardiac Pacing'. Insieme formano una fingerprint unica.

Cita questo