TY - JOUR
T1 - Clinical target volume delineation including elective nodal irradiation in preoperative and definitive radiotherapy of pancreatic cancer
AU - Caravatta, Luciana
AU - Sallustio, Giuseppina
AU - Pacelli, Fabio
AU - Padula, Gilbert D.A.
AU - Deodato, Francesco
AU - Macchia, Gabriella
AU - Massaccesi, Mariangela
AU - Picardi, Vincenzo
AU - Cilla, Savino
AU - Marinelli, Alberto
AU - Cellini, Numa
AU - Valentini, Vincenzo
AU - Morganti, Alessio Giuseppe
PY - 2012
Y1 - 2012
N2 - ABSTRACT: BACKGROUND: Radiotherapy is widely used in the treatment of pancreatic cancer. Currently, recommendation has been given for the delineation of the clinical target volume (CTV) in adjuvant radiotherapy. Based on recently reviewed pathologic data, the aim of this study is to propose criteria for the CTV definition and delineation including elective nodal irradiation (ENI) in the preoperative and definitive treatment of pancreatic cancer. METHODS: The anatomical structures of interest, as well as the abdominal vasculature were identified on intravenous contrast-enhanced CT scans of two different patients with pancreatic cancer of the head and the body. To delineate the lymph node area, a margin of 10 mm was added to the arteries. RESULTS: We proposed a set of guidelines for elective treatment of high-risk nodal areas and CTV delineation. Reference CT images were provided. CONCLUSIONS: The proposed guidelines could be used for preoperative or definitive radiotherapy (RT) for carcinoma of the head and body of the pancreas. Further clinical investigations are needed to validate the defined CTVs.
AB - ABSTRACT: BACKGROUND: Radiotherapy is widely used in the treatment of pancreatic cancer. Currently, recommendation has been given for the delineation of the clinical target volume (CTV) in adjuvant radiotherapy. Based on recently reviewed pathologic data, the aim of this study is to propose criteria for the CTV definition and delineation including elective nodal irradiation (ENI) in the preoperative and definitive treatment of pancreatic cancer. METHODS: The anatomical structures of interest, as well as the abdominal vasculature were identified on intravenous contrast-enhanced CT scans of two different patients with pancreatic cancer of the head and the body. To delineate the lymph node area, a margin of 10 mm was added to the arteries. RESULTS: We proposed a set of guidelines for elective treatment of high-risk nodal areas and CTV delineation. Reference CT images were provided. CONCLUSIONS: The proposed guidelines could be used for preoperative or definitive radiotherapy (RT) for carcinoma of the head and body of the pancreas. Further clinical investigations are needed to validate the defined CTVs.
KW - PANCREATIC CANCER
KW - PANCREATIC CANCER
UR - http://hdl.handle.net/10807/32845
U2 - 10.1186/1748-717X-7-86
DO - 10.1186/1748-717X-7-86
M3 - Article
SN - 1748-717X
VL - 7
SP - 86
EP - 86
JO - Radiation Oncology
JF - Radiation Oncology
ER -
