Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.

Stefan Hohaus, Maurizio Martini, Francesco D'Alo', Luigi Maria Larocca, Giuseppina Massini, Marianna Criscuolo, Maria Teresa Voso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

29 Citazioni (Scopus)

Abstract

We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.
Lingua originaleEnglish
pagine (da-a)1352-1356
Numero di pagine5
RivistaLeukemia Research
Volume33
Stato di pubblicazionePubblicato - 2009

Keywords

  • Hodgkin lymphoma
  • Interleukin
  • Polimorphism

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