Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma

Stefan Hohaus; Manuela Giachelia; Giuseppina Massini; Barbara Vannata; Marianna Criscuolo; Maurizio Martini; Francesco D'Alo'; Maria Teresa Voso; Luigi Maria Larocca; Giuseppe Leone

doi:10.1016/j.leukres.2009.01.009

Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma

Stefan Hohaus
, Manuela Giachelia
, Giuseppina Massini
, Barbara Vannata
, Marianna Criscuolo
, Maurizio Martini
, Francesco D'Alo'
, Maria Teresa Voso
, Luigi Maria Larocca
, Giuseppe Leone

Risultato della ricerca: Contributo in rivista › Articolo

29 Citazioni (Scopus)

Abstract

We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.

Lingua originale	Inglese
pagine (da-a)	1352-1356
Numero di pagine	5
Rivista	Leukemia Research
Volume	33
DOI	https://doi.org/10.1016/j.leukres.2009.01.009
Stato di pubblicazione	Pubblicato - 2009

Keywords

Adult
DNA, Neoplasm
Epstein-Barr Virus Infections
Female
Gene Amplification
Genetic Variation
Herpesvirus 4, Human
Hodgkin Disease
Homozygote
Humans
Interleukin-10
Male
Middle Aged
Neoplasm Staging
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prognosis
Promoter Regions, Genetic

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10.1016/j.leukres.2009.01.009

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title = "Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma",

abstract = "We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.",

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author = "Stefan Hohaus and Manuela Giachelia and Giuseppina Massini and Barbara Vannata and Marianna Criscuolo and Maurizio Martini and Francesco D'Alo' and Voso, \{Maria Teresa\} and Larocca, \{Luigi Maria\} and Giuseppe Leone",

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doi = "10.1016/j.leukres.2009.01.009",

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AU - Hohaus, Stefan

AU - Giachelia, Manuela

AU - Massini, Giuseppina

AU - Vannata, Barbara

AU - Criscuolo, Marianna

AU - Martini, Maurizio

AU - D'Alo', Francesco

AU - Voso, Maria Teresa

AU - Larocca, Luigi Maria

AU - Leone, Giuseppe

PY - 2009

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N2 - We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.

AB - We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.

KW - Adult

KW - DNA, Neoplasm

KW - Epstein-Barr Virus Infections

KW - Female

KW - Gene Amplification

KW - Genetic Variation

KW - Herpesvirus 4, Human

KW - Hodgkin Disease

KW - Homozygote

KW - Humans

KW - Interleukin-10

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Prognosis

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KW - DNA, Neoplasm

KW - Epstein-Barr Virus Infections

KW - Female

KW - Gene Amplification

KW - Genetic Variation

KW - Herpesvirus 4, Human

KW - Hodgkin Disease

KW - Homozygote

KW - Humans

KW - Interleukin-10

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Promoter Regions, Genetic

UR - http://hdl.handle.net/10807/26201

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SP - 1352

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JO - Leukemia Research

JF - Leukemia Research

ER -

Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma

Abstract

Keywords

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