Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma

Stefan Hohaus, Maurizio Martini, Francesco D'Alo', Luigi Maria Larocca, Manuela Giachelia, Giuseppina Massini, Barbara Vannata, Marianna Criscuolo, Maria Teresa Voso, Giuseppe Leone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

29 Citazioni (Scopus)

Abstract

We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.
Lingua originaleEnglish
pagine (da-a)1352-1356
Numero di pagine5
RivistaLeukemia Research
Volume33
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Adult
  • DNA, Neoplasm
  • Epstein-Barr Virus Infections
  • Female
  • Gene Amplification
  • Genetic Variation
  • Herpesvirus 4, Human
  • Hodgkin Disease
  • Homozygote
  • Humans
  • Interleukin-10
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Promoter Regions, Genetic

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