Clinical management and patient outcomes of acute lower gastrointestinal bleeding. A multicenter, prospective, cohort study

Franco Radaelli, Leonardo Frazzoni, Alessandro Repici, Emanuele Rondonotti, Alessandro Mussetto, Valentina Feletti, Cristiano Spada, Gianpiero Manes, Sergio Segato, Eleonora Grassi, Elisa Maria Grassi, Alessandro Musso, Emilio Di Giulio, Chiara Coluccio, Mauro Manno, Germana De Nucci, Virginia Festa, Alfredo Di Leo, Mario Marini, Martina MariniLuca Ferraris, Marcella Feliziani, Arnaldo Amato, Paola Soriani, Chiara Del Bono, Silvia Paggi, Cesare Hassan, Lorenzo Fuccio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background & aim: Although acute lower GI bleeding (LGIB) represents a significant healthcare burden, prospective real-life data on management and outcomes are scanty. Present multicentre, prospective cohort study was aimed at evaluating mortality and associated risk factors and at describing patient management. Methods: Adult outpatients acutely admitted for or developing LGIB during hospitalization were consecutively enrolled in 15 high-volume referral centers. Demographics, comorbidities, medications, interventions and outcomes were recorded. Results: Overall 1,198 patients (1060 new admissions;138 inpatients) were included. Most patients were elderly (mean-age 74±15 years), 31% had a Charlson-Comorbidity-Index ≥3, 58% were on antithrombotic therapy. In-hospital mortality (primary outcome) was 3.4% (95%CI 2.5–4.6). At logistic regression analysis, independent predictors of mortality were increasing age, comorbidity, inpatient status, hemodynamic instability at presentation, and ICU-admission. Colonoscopy had a 78.8% diagnostic yield, with significantly higher hemostasis rate when performed within 24-hours than later (21.3% vs.10.8%, p = 0.027). Endoscopic hemostasis was associated with neither in-hospital mortality nor rebleeding. A definite or presumptive source of bleeding was disclosed in 90.4% of investigated patients. Conclusion: Mortality in LGIB patients is mainly related to age and comorbidities. Although early colonoscopy has a relevant diagnostic yield and is associated with higher therapeutic intervention rate, endoscopic hemostasis is not associated with improved clinical outcomes [ClinicalTrial.gov number: NCT 04364412].
Lingua originaleEnglish
pagine (da-a)1141-1147
Numero di pagine7
RivistaDigestive and Liver Disease
Volume53
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Colonoscopy
  • Endoscopic hemostasis
  • Lower GI bleeding

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