Clinical interpretation of genetic variants in arrhythmogenic right ventricular cardiomyopathy

Mireia Alcalde, Oscar Campuzano, Georgia Sarquella-Brugada, Elena Arbelo, Catarina Allegue, Sara Partemi, Anna Iglesias, Antonio Oliva, Josep Brugada, Ramon Brugada

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)


Arrhythmogenic right ventricular cardiomyopathy is an inherited cardiac entity characterized by right ventricular, or biventricular, fibrofatty replacement of myocardium. Structural alterations may lead to sudden cardiac death, mainly in young males during exercise. Autosomal dominant pattern of inheritance is reported in most parts of pathogenic genetic variations identified. Currently, 13 genes have been associated with the disease but nearly 40 % of clinically diagnosed cases remain without a genetic diagnosis. New genetic technologies allow further genetic analysis, generating a significant amount of genetic data in novel genes, which is often classified as of ambiguous significance. We focus on genetic advances of arrhythmogenic right ventricular cardiomyopathy, helping clinicians to interpret and translate genetic data into clinical practice.
Lingua originaleEnglish
pagine (da-a)288-303
Numero di pagine16
RivistaClinical Research in Cardiology
Stato di pubblicazionePubblicato - 2015


  • ARVD


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